Results 91 to 100 of about 51,339 (313)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
2015 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 464 fertility clinics in operation in 2015 that provided and verified data on the outcomes of all ART cycles started in their clinics. Of the 231,936 ART cycles performed in 2015 at these reporting clinics,
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Asian Journal of Andrology, 2016 Postcopulatory sexual selection through sperm competition may be an important evolutionary force affecting many reproductive traits, including sperm morphometrics.
Julian Santiago-Moreno +8 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
2013 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 467 fertility clinics in operation in 2013 that provided and verified data on the outcomes of all ART cycles started in their clinics. Of the 190,773 ART cycles performed in 2013 at these reporting clinics,
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
2012 Assisted Reproductive Technology Report \u2014 Graphs and Charts
Graphs and charts from the 2012 Assisted Reproductive Technology National Summary Report provide an in-depth picture of the type, number, and outcome of ART cycles performed in U.S. fertility clinics.
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2017 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 448 US fertility clinics in operation in 2017 that provided and verified data on the outcomesof all ART cycles started in their clinics.echnology Fertility Clinic Success Rates Report. Of the 284,385 cycles
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Assisted reproductive techniques in the prevention of mitochondrial diseases
Universidad Médica Pinareña, 2020 Introduction: the mitochondrion is an important organelle that has its own DNA that is sensitive to mutations. These mutations can cause mitochondrial diseases, a heterogeneous group that suggests mitochondrial dysfunction.
Felipe De Jesús López-Catá +2 more
doaj +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source