Results 151 to 160 of about 688,418 (377)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Fatherhood and sperm DNA damage in testicular cancer patients [PDF]

open access: yes, 2018
Testicular cancer (TC) is one of the most treatable of all malignancies and the management of the quality of life of these patients is increasingly important, especially with regard to their sexuality and fertility.
Lenzi, Andrea   +3 more
core   +1 more source

Assisted Reproductive Techniques and Catholicism(s) in the US

open access: yesReligion and Gender, 2019
Abstract Assisted Reproductive Techniques (ART s) have proposed a new way of understanding notions of sexuality, reproduction, gestation, and family, and these transformations have arguably been a challenge in the religious field. This study aims to analyze the stances taken within the Catholic spectrum in the United States on ART s.
openaire   +3 more sources

Assisted Reproductive Techniques in a Patient with History of Venous Thromboembolism: A Case Report and Review of Literature

open access: yesJournal of Human Reproductive Sciences, 2018
We report a patient with a history of venous thrombosis following oral contraceptive pills who was planned for in vitro fertilization (IVF)-intracytoplasmic sperm injection for male factor infertility.
S. Gurunath   +2 more
semanticscholar   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

SeeAction: Towards Reverse Engineering How-What-Where of HCI Actions from Screencasts for UI Automation [PDF]

open access: yesICSE 2025
UI automation is a useful technique for UI testing, bug reproduction, and robotic process automation. Recording user actions with an application assists rapid development of UI automation scripts, but existing recording techniques are intrusive, rely on OS or GUI framework accessibility support, or assume specific app implementations.
arxiv  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Mitochondrial DNA transfer: some reflections from the United Kingdom [PDF]

open access: yes, 2015
Recent medical advances and subsequent law reform in the United Kingdom have reignited debate about the ethics of mitochondrial DNA donation and transfer.
McLean, Sheila A.
core  

GnRH analogues: applications in assisted reproductive techniques [PDF]

open access: yesEuropean Journal of Endocrinology, 2008
The ability to prevent an endogenous LH surge revolutionised the efficacy of assisted reproductive techniques (ART) such that GnRH agonists were rapidly adopted in the 1980s. Prior to this, premature luteinisation occurred in up to 25% of superovulated cycles leading to cycle cancellation and severely compromised outcomes.
openaire   +3 more sources

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

open access: yesMolecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon   +13 more
wiley   +1 more source

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