Results 41 to 50 of about 47,671 (263)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Ethics: use and misuse of assisted reproductive techniques across species

open access: yesReproduction and Fertility, 2021
The boundaries of what we are able to do using ARTs are fast-moving. In both human and veterinary medicine, this presents a fundamental question: ‘Just because we can, should we?’ or, to rephrase the same question: ‘How can we distinguish between what is
Madeleine L H Campbell
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A singular relationship: the bonds between gestational carriers and intended parents in surrogacy between Ukraine and Argentina

open access: yesSalud Colectiva
Surrogacy is a practice that generates controversy, especially in contexts where regulation is scarce or nonexistent. In Argentina, although there is no specific legislation, this practice involves significant judicial mediation and various legal ...
Lucía Ariza, Natacha Salomé Lima
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Psychosocial Problems during Infertility Treatment [PDF]

open access: yesPsikiyatride Güncel Yaklaşımlar, 2013
Infertility is a complex situation crisis which is often psychologically-threatening and emotionally stressful for both partners as well as economically expensive and causes physical pain due to the operations performed for diagnosis and treatment ...
Nurcan Kirca, Turkan Pasinlioglu
doaj  

Assisted Reproductive Techniques and Cardiovascular Risk

open access: yesJournal of the American College of Cardiology, 2019
We read with great interest the study by Meister et al. [(1)][1] in a recent issue of the Journal . In this longitudinal study of children conceived by assisted reproductive techniques (ART), the investigators detected signs of premature vascular aging and also a significant 6-fold increase in ...
Naga Venkata, Pothineni   +2 more
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Asymptomatic Leukocytospermia and Assisted Reproductive Technology Outcomes: Reason for concern? [PDF]

open access: yesInternational Brazilian Journal of Urology
Leukocytospermia, defined as ≥1×106 white blood cells (WBC)/ml of semen, is a condition frequently observed in infertile men. While symptomatic leukocytospermia is often associated with genital tract infections and managed accordingly, the clinical ...
Marie-Christin Reich   +3 more
doaj   +1 more source

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