Results 41 to 50 of about 51,339 (313)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A Review of the Rulings by Muslim Jurists on Assisted Reproductive Technology and Reproductive Tissue Transplantation

Religions, 2021
Developments in organ donation and transplantation continue to generate controversy, especially in the field of reproductive medicine. Techniques used in assisted reproductive technology (ART), such as artificial insemination, in vitro fertilisation (IVF)
Zachariah Matthews
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Ethics: use and misuse of assisted reproductive techniques across species

Reproduction and Fertility, 2021
The boundaries of what we are able to do using ARTs are fast-moving. In both human and veterinary medicine, this presents a fundamental question: ‘Just because we can, should we?’ or, to rephrase the same question: ‘How can we distinguish between what is
Madeleine L H Campbell
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Asymptomatic Leukocytospermia and Assisted Reproductive Technology Outcomes: Reason for concern? [PDF]

International Brazilian Journal of Urology
Leukocytospermia, defined as ≥1×106 white blood cells (WBC)/ml of semen, is a condition frequently observed in infertile men. While symptomatic leukocytospermia is often associated with genital tract infections and managed accordingly, the clinical ...
Marie-Christin Reich, Natalie Heide, Peter Humaidan, Sandro C. Esteves   +3 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Cross‐border reproductive care

, 2021
The most common forms of fertility treatments provided within cross‐border reproductive care (CBRC) are assisted reproductive technologies, namely in‐vitro fertilization and ICSI, for many indications.
Patrizio, Pasquale, Salama, Mahmoud, Lynn M. Westphal, Marcia C. Inhorn, Pasquale Patrizio, Westphal, Lynn M, Inhorn, Marcia C, Mahmoud Salama   +7 more
core   +1 more source

A singular relationship: the bonds between gestational carriers and intended parents in surrogacy between Ukraine and Argentina

Salud Colectiva
Surrogacy is a practice that generates controversy, especially in contexts where regulation is scarce or nonexistent. In Argentina, although there is no specific legislation, this practice involves significant judicial mediation and various legal ...
Lucía Ariza, Natacha Salomé Lima
doaj   +1 more source

Assisted Reproductive Techniques and Cardiovascular Risk

Journal of the American College of Cardiology, 2019
We read with great interest the study by Meister et al. [(1)][1] in a recent issue of the Journal . In this longitudinal study of children conceived by assisted reproductive techniques (ART), the investigators detected signs of premature vascular aging and also a significant 6-fold increase in ...
Naga Venkata, Pothineni, Swathi, Kovelamudi, Suma, Kantipudi   +2 more
openaire   +2 more sources