Results 41 to 50 of about 6,480,186 (210)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Out-of-pocket payment for assisted reproductive techniques in the public health sector in South Africa - how do households cope? [PDF]
, 2011 Includes bibliographical references.In South Africa assisted reproductive techniques (ART) are poorly covered by health insurances or government funding thereby often inflicting out-of-pocket payment (OPP) on patients.
Sherwood, Kerry Anne
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
2010 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 443 fertility clinics in operation in 2010 that provided and verified data on the outcomes of all ART cycles started at their clinics.
core
, 2023 Assisted reproduction has recently entered the field of interest of researchers and physicians and has become an open topic of research. Considering the 1.5 million babies born with assisted reproductive techniques today, we can also understand why this ...
Yapıcı, Tunahan, Aghayeva, Aynura
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
2014 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 458 fertility clinics in operation in 2014 that provided and verified data on the outcomes of all ART cycles started in their clinics. Of the 208,604 ART cycles performed in 2014 at these reporting clinics,
core
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
2012 Assisted Reproductive Technology National Summary Report [PDF]
The data for this national report come from the 456 fertility clinics in operation in 2012 that provided and verified data on the outcomes of all ART cycles started in their clinics. Of the 176,247 ART cycles performed in 2012 at these reporting clinics,
core