Results 41 to 50 of about 216,273 (311)

A Bayesian reevaluation of randomized controlled trials in assisted reproductive technology: quantifying evidence strength for null and alternative hypotheses

Frontiers in Endocrinology
IntroductionMany randomized controlled trials (RCTs) in assisted reproductive technology (ART) face widespread misinterpretation of statistically non-significant results within the conventional frequentist framework.
Jiayi Gao, Tian Tian, Kalbinur Kayimu, Yi Yuan, Yongyan Chen, Yu Fu, Rui Chen, Fang Liu, Yunjun Zhang, Yuanyuan Wang   +9 more
doaj   +1 more source

Improving Fertility in Non-obstructive Azoospermia: Results from an Autologous Bone Mar-row-Derived Mesenchymal Stromal/Stem Cell Phase I Clinical Trial [PDF]

International Journal of Fertility and Sterility
Background: In this phase I clinical trial, our primary objective was to develop an innovative therapeutic approachutilizing autologous bone marrow-derived mesenchymal stromal/stem cells (BM-MSCs) for the treatment of nonobstructiveazoospermia (NOA ...
Rano Zhankina, Ulanbek Zhanbyrbekuly, Manarbek Askarov, Afshin Zare, Nazanin Jafari, Dana Saipiyeva, Ravil Sherkhanov, Daniyar Akhmetov, Alireza Hashemi, Mojtaba Farjam, Nader Tanideh, Behrouz Aflatoonian, Nadiar Maratovich Mussin, Asset Askerovich Kaliyev, Yerlan Sultangereyev, Hanieh Baneshi, Reza Shirazi, Mahdi Mahdipour, Shabnam Bakhshalizadeh, Farhad Rahmanifar, Amin Tamadon   +20 more
doaj   +1 more source

Assisted Reproduction Technology and Perinatal Outcomes: A Review [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2017
Introduction: Approximately 9% of couples worldwide face with infertility problem in some period of their life. Assisted reproductive technology (ART) is a common choice of treatment for many infertile couples that its case is male or female factor, or ...
Ommolbanin Zare, Farin Soleimani
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Perfil de puérperas submetidas a métodos de reprodução assistida [Profile of postpartum women submitted to assisted reproduction methods] [Perfil de puérperas sometidas a métodos de reproducción asistida]

Revista Enfermagem UERJ, 2012
Estudo cujo objetivo foi discutir o perfil de mulheres submetidas a métodos de reprodução assistida em hospital privado do Município de São Paulo, em 2009. Pesquisa quantitativa, descritiva, exploratória, transversal, de nível I.
Alexandra Celento Vasconcellos da Silva, Maria Mercedes Fernandes Samperiz, Andréa Gomes da Costa Mohallem, Octavio Muniz da Costa Vargens   +3 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Psychological Distress, Dyadic Coping, and Quality of Life in Infertile Clients Undergoing Assisted Reproductive Technology in China: A Single-Center, Cross-Sectional Study

Journal of Multidisciplinary Healthcare, 2022
Jie Bai,1 Jinxia Zheng,1 Yueyan Dong,1 Ke Wang,1 Cheng Cheng,2 Hui Jiang3 1Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of
Bai J, Zheng J, Dong Y, Wang K, Cheng C, Jiang H   +5 more
doaj  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evaluation of the Efficacy and Side Effects of Catheter-Specific Intrauterine Insemination in Infertile Couples, a Randomized Clinical Trial

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Intrauterine insemination (IUI) is one of the assisted reproductive techniques, which increases the likelihood of egg being exposed to sperm in the uterus and thus the chances of pregnancy.
Elham Naghshineh, Hatav Ghasemi Tehrani, Behnaz Khani, Nasrin Bagheri, Najmeh Tavakol, Fatemeh Maghool   +5 more
doaj  

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source