Results 91 to 100 of about 5,493 (218)

Reproductive health of the population as an object of attention of gender-sensitive social work

open access: yesНауковий Вісник Південноукраїнського Національного Педагогічного Університету імені К. Д. Ушинського
Activities to protect the reproductive health of the population are one of the priority areas of social work. In modern medical and social work, a gender-sensitive approach is being actualised, which shows that gender is one of the leading factors in ...
Honcharenko Olena, Lutsenko Olena
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Les expériences de mères et d’un parent non binaire douloureux·ses chroniques : entre temporalités handicapées et genrées 

open access: yesEnfances, Familles, Générations
Research framework: Mothers and gender-diverse parents with chronic pain have their own unique social experiences. In addition to having to juggle a double working day (double journée de travail), they also experience particular temporalities.
Marieke Hassell-Crépeau
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Effect of female genital mutilation (FGM) experiences on pregnancy outcomes among reproductive aged women in the Gambia: a regression analysis of the 2019–2020 Gambia demographic and health survey

open access: yesDiscover Public Health
Background Female genital mutilation/cutting (FGM/C) remains a significant threat to the health and human rights women and girls globally. It has been linked to severe health issues, substantial morbidity, a healthcare burden, and poor health indicators.
Desmond Klu   +6 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Trends and Disparities in Firearm Injuries Among Emerging Adults: A 15-Year Analysis of Emergency Department Admissions in the U.S.

open access: yesAJPM Focus
Introduction: Firearm injuries in the U.S. are rising, with emerging adults (aged 18–24 years) experiencing disproportionately high rates of fatal and nonfatal incidents.
Morayo O. Akande, MPH   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

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