Results 91 to 100 of about 1,210,714 (308)

The work of the encyclopedia in the age of electronic reproduction

open access: yesFirst Monday, 1998
Most discussion on the impact of the shift from print to electronic publishing has focused on issues like the fate of linear narrative, notions of authorship, and copyright. This article examines how the digitization of literature affects the craft of editing, and the everyday work of content producers. It focuses on the Encyclopaedia Britannica, which
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Generating functionals and Gaussian approximations for interruptible delay reactions

open access: yes, 2015
We develop a generating functional description of the dynamics of non-Markovian individual-based systems, in which delay reactions can be terminated before completion.
Brett, Tobias, Galla, Tobias
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Situer le Care au cœur de la ville : le travail de reproduction en dehors du travail domestique et du travail des femmes

open access: yesGéoProximitéS
This article, based on fieldwork in public parks and gardens in Rennes, Strasbourg, and Le Mans, examines the maintenance work of municipal gardeners as a form of urban care, traditionally associated with female-dominated professions.
Elsa Koerner
doaj  

Associations between climate change-related factors and sexual health: A scoping review

open access: yesGlobal Public Health
There is growing attention to the ways in which climate change may affect sexual health, yet key knowledge gaps remain across global contexts and climate issues. In response, we conducted a scoping review to examine the literature on associations between
Carmen H. Logie   +7 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Cachez ce care que je ne saurais voir. Les ajustements méthodologiques d’une étude féministe du travail du care dans le logement collectif

open access: yesGéoProximitéS
Making domestic and care work visible, quantifying and qualifying in order to recognize, distribute, share, value or outsource it among the society has been one of the major challenges of the feminist project for decades.
Benjamin Leclercq   +3 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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