Results 121 to 130 of about 1,210,714 (308)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Lived experiences of migrant men witnessing and surviving sexual violence in European transit spaces

Globalization and Health
Background Despite increased scholarly attention to sexual violence, victimization among migrant men and boys remains under researched. This study aims to explore 1) migrant men’s views on and understandings of sexual victimization, 2) their own ...
Leni Linthout, Ilse Derluyn, Caroline Desombre, Massil Benbouriche, Ines Keygnaert   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Impact of night shift work on women's fertility, pregnancy and menopause

Frontiers in Sleep
A growing body of literature examines how shift work affects different aspects of women's reproductive cycles, ranging from fertility to pregnancy to menopause. This review summarizes what is known about how shift work affects women's reproductive cycles,
Christina Y. Lee, Katherine Moawad, Grace W. Pien   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Radical and Utopian or Partnership between Men and Women?

Österreichische Zeitschrift für Geschichtswissenschaften
This contribution explores the interplay between labour and feminist activism in Austria during the 1970s and 1980s. Focusing on the often overlooked nexus of the women’s liberation movement and the trade union movement, the analysis looks into the ...
Veronika Helfert
doaj   +1 more source

Gender Transformative Philanthropy [PDF]

, 2012
As foundations and other philanthropic institutions assess where they can maximize the social return on their charitable investments, many are looking at issues of gender norms and gender equity.
Alicia Jay, Jacqueline Ebanks, Kimberly Otis, Riki Wilchins, Stephen Foster, Susan Wefald   +5 more
core  

Reproduction and work [PDF]

BMJ, 1987
openaire   +1 more source

On Reproductive Work in Spain

La caiguda de la fertilitat d'Espanya des de finals del segle XX pot semblar reflectir un desig minvant de fills. No obstant això, les decepcions reproductives derivades de les desigualtats de gènere fan que moltes dones espanyoles posposen la maternitat i experimentin problemes de fertilitat relacionats amb l'edat.
Marre, Diana||, San Román, Beatriz||
openaire   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source