Results 121 to 129 of about 1,118 (129)
ssDNA phage FLiP resides in dsDNA form in resistant Flavobacterium host
Mäkelä K +4 more
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
REPSA: General combinatorial approach for identifying preferred ligand–DNA binding sequences
Methods, 2007Most DNA-binding ligands, ranging from protein transcription factors to small molecule antineoplastic agents, recognize duplex DNA with some degree of sequence specificity. Determining this binding specificity is important for biochemists, molecular biologists, and medicinal chemists.
Michael W, Van Dyke +2 more
openaire +2 more sources
Identification of Preferred Distamycin−DNA Binding Sites by the Combinatorial Method REPSA
Bioconjugate Chemistry, 1997The combinatorial method restriction endonuclease protection, selection, and amplification (REPSA) was used to determine the preferred duplex DNA binding sites of the peptide N-methylpyrrolecarboxamide antibiotic distamycin A. After 12 rounds of REPSA, several sequences were identified that bound distamycin with an apparent affinity of 2-20 nM.
P, Hardenbol, J C, Wang, M W, Van Dyke
openaire +2 more sources
Identification of preferred actinomycin–DNA binding sites by the combinatorial method REPSA
Bioorganic & Medicinal Chemistry, 2001An important question in the study of ligand-DNA interactions is the determination of binding specificity. Here, we used the combinatorial method restriction endonuclease protection, selection, and amplification (REPSA) to identify the preferred duplex DNA-binding sites of the antineoplastic agent actinomycin D.
J, Shen, J C, Wang, M W, Van Dyke
openaire +2 more sources
REPSA: Combinatorial Approach for Identifying Preferred Drug-DNA Binding Sequences
2009Many DNA-binding small molecules, typically those with a molecular mass less than 1,000 g/mol, recognize duplex DNA with some degree of sequence specificity. These include drugs used to treat several human diseases, including viral and bacterial infections, malaria, and cancer.
openaire +2 more sources