Results 201 to 210 of about 139,385 (306)

Quantitative Visualization of Intracellular Nanometabolism Using Peak‐Shifted Dual‐State Emissive FRET Nanoprobes

open access: yesAdvanced Science, EarlyView.
This study reveals the long‐elusive intracellular dissolution mechanism of carrier‐free nanomedicines. By utilizing peak‐shifted dual‐state emissive FRET nanoprobes (PDFNPs) that undergo a distinct ratiometric fluorescence peak shift upon disassembly, we achieve real‐time, quantitative tracking of dissolution kinetics in live cells.
Farsai Taemaitree   +18 more
wiley   +1 more source

WGM Single‐Molecule Validation of pH‐Dependent Molecular Energetics at Gold Nanointerfaces: Influence of Buffer Molecules on Glyphosate Ligand Binding

open access: yesAdvanced Science, EarlyView.
Single‐molecule optical sensing reveals how pH and buffer molecules regulate glyphosate interactions with gold nanorods. Combined experiments and theoretical calculations show that changes in molecular charge and competition from buffer species determine whether glyphosate binds transiently or persistently.
Kulathunga Mudalige Kalani Perera   +3 more
wiley   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu   +15 more
wiley   +1 more source

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

open access: yesAdvanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu   +14 more
wiley   +1 more source

Interfacial Tandem Catalysis Over a CuSn(OH)6/Co Heterostructure Enables Efficient Electroreduction of Nitrate to Ammonia

open access: yesAdvanced Science, EarlyView.
Interfacial tandem catalysis is developed for efficient electrochemical reduction of NO3− to NH3 over a CuSn(OH)6/Co heterostructure. CuSn(OH)6 accelerates the rate‐determining NO3−‐to‐*NO2 conversion, whereas Co promotes H2O dissociation to enhance *H supply for the rapid hydrogenation of *NO2 intermediate to NH3.
Yuan‐Yuan Hei   +7 more
wiley   +1 more source

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