Results 211 to 220 of about 4,264,708 (345)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

No evidence for disruption of empathy and mentalizing by face coverage in multimodal settings. [PDF]

Sci Rep
Landmann E, Straub IF, Böckler A.
europepmc   +1 more source

Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall

Science, 2002
K. Nakazawa, M. Quirk, R. Chitwood, Masahiko Watanabe, M. Yeckel, L. D. Sun, Akira Kato, C. Carr, D. Johnston, M. Wilson, S. Tonegawa   +10 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Pulmonary hypertension in pediatric patients with cystic fibrosis during acute pulmonary exacerbations: prevalence and associated factors. [PDF]

BMC Pulm Med
Roshanzamir Z, Mohammadi F, Shirzadi R.
europepmc   +1 more source

Odds ratios and 95% confidence intervals of micronutrient intakes below the estimated average requirement (EAR) in men according to frailty groups.

Subeen Kim (11714313), Haerang Lee (19231885), Minji Kang (1713256)   +2 more
openalex   +1 more source

An Extended Rule of the SysML Requirement Diagram Transformation into OWL Ontologies

, 2020
Ahmad Ashari, Anny Kartika Sari, Helna Wardhana, Universitas Gadjah Mada, Helna Wardhana, Universitas Gadjah Mada   +5 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Procedures as Proxy: Re-Centering Continuity and Comprehensiveness. [PDF]

Ann Fam Med
Wheat S, Le M, Herzog A.
europepmc   +1 more source