Results 61 to 70 of about 6,864 (265)

Association Rule Mining for Requirement Elicitation Techniques in IT Projects [PDF]

open access: yesAnnals of computer science and information systems, 2023
Denys Gobov, Nikolai Sokolovskiy
doaj   +1 more source

Enhancing Misuse Cases With Risk Assessment for Safety Requirements

open access: yesIEEE Access, 2020
Risk-driven requirements elicitation represents an approach that allows assignment of appropriate countermeasure for the protection of the Information System (IS) depending on the risk level.
Oluwasefunmi T. Arogundade   +3 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Issues in Requirements Elicitation [PDF]

open access: yes, 1992
Abstract : There are many problems associated with requirements engineering, including problems in defining the system scope, problems in fostering understanding among the different communities affected by the development of a given system, and problems in dealing with the volatile nature of requirements.
Kyo C. Kang, Michael G. Christel
openaire   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

The application of and unresolved problems regarding the use of objectives in software engineering

open access: yesIngeniería e Investigación, 2012
One of the first items which should be identified in resolving a problem or need is an objective in the various fields of knowledge as it enables determining which results must be achieved.
Luis Alfonso Lezcano Rodríguez   +2 more
doaj  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Exploring Requirements Engineering for Machine Learning via a Product Case Study

open access: yesProceedings of the International Florida Artificial Intelligence Research Society Conference
Requirements Engineering (RE) is a well-defined process in software development. Through customer requirement elicitation techniques, Non-Functional Requirements (NFRs) and the Functional Requirements (FRs) that implement them, are defined.
Lynn Vonderhaar   +3 more
doaj   +1 more source

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