Results 61 to 70 of about 663,098 (242)
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
QUALITATIVE COMPARISONS OF ELICITATION TECHNIQUES IN REQUIREMENT ENGINEERING [PDF]
, 2019 It is often emphasized that the quality of elicited requirement is mostly influenced by the elicitation techniques employed to gather software requirements.
Ogunbanwo, Afolakemi +4 more
core
A Systematic Review of AI-Enabled Frameworks in Requirements Elicitation
IEEE AccessEmploying Artificial Intelligence techniques to address challenges in requirements elicitation is gaining traction. Although nine systematic literature reviews have been published on AI-based solutions in the requirements elicitation domain, to our ...
Vaishali Siddeshwar +2 more
doaj +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
FEBS Open Bio, EarlyView.Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
User Review Analysis for Requirement Elicitation [PDF]
, 2020 Online reviews are an important channel for requirement elicitation. However, requirement engineers face challenges when analysing online user reviews, such as data volumes, technical supports, existing techniques, and legal barriers.
Wang, Juan
core +1 more source
An Investigation of Prototyping Technique in Pakistani Software Industry
Mehran University Research Journal of Engineering and Technology, 2019 Requirements elicitation is one of the important and major activities within the Requirements Engineering phase. There are different techniques used for requirement elicitation process.
Muhammad Janas Khan, Rafiq Ahmad Khan
doaj
FEBS Open Bio, EarlyView.The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Evaluation of elicitation methods to quantify Bayes linear models [PDF]
, 2010 The Bayes linear methodology allows decision makers to express their subjective beliefs and adjust these beliefs as observations are made. It is similar in spirit to probabilistic Bayesian approaches, but differs as it uses expectation as its primitive ...
Bedford, T.J. +2 more
core +2 more sources