Results 41 to 50 of about 663,098 (242)
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Ontology Driven Requirement Specification
JISR on Computing, 2017 Requirement engineering (RE) process is an important step of software development lifecycle and it includes a variety of activities starting with requirement elicitation to requirement documentation. This form of engineering is the backbone of a quality
Adeel Ahmed, Fabeha Maniar
doaj +1 more source
Using expert-elicitation to deliver biodiversity monitoring priorities on a Mediterranean island.
PLoS ONE, 2022 Biodiversity monitoring plays an essential role in tracking changes in ecosystems, species distributions and abundances across the globe. Data collected through both structured and unstructured biodiversity recording can inform conservation measures ...
J Peyton +22 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
IEEE Access, 2020 Clinical software is a fundamental tool for supporting healthcare systems because it improves the quality of patient care and automatizes the most frequently performed clinical tasks. Nevertheless, since health systems include various components, such as
Gaston Marquez, Carla Taramasco
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Strategies to Minimize Problems in Global Requirements Elicitation
CLEI Electronic Journal, 2008 Many challenges arise in global software development projects, most of which are related to the lack of face-to-face communication and people’s need to feel comfortable with the technology that they use. In this paper we introduce a methodology to detect
Gabriela N Aranda +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Intermediary's Elicitation and Patron's Retrieval Satisfaction [PDF]
, 2010 [[abstract]]An elicitation is a verbal request for information reflecting one's interests, concerns or perplexities in conversation. Elicitation behavior in studies of information retrieval interaction is, in fact, the micro-level of information-seeking ...
Wu, Mei-Mei;Liu, Ying-Hasng;Chiang, Hsing-Jung +3 more
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