Results 31 to 40 of about 6,864 (265)

Ontology-Driven Guidance for Requirements Elicitation [PDF]

, 2011
Requirements managers aim at keeping their sets of requirements well-defined, consistent and up to date throughout a project's life cycle. Semantic web technologies have found many valuable applications in the field of requirements engineering, with most of them focusing on requirements analysis.
Stefan Farfeleder, Thomas Moser, Andreas Krall, Tor Stålhane, Inah Omoronyia, Herbert Zojer   +5 more
openaire   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Fuzzy Specification in Real Estate Market Decision Making [PDF]

International Journal of Computational Intelligence Systems, 2010
In this paper we present a software tool designed as a decision aid system for all actors being involved when buying or selling real state, client and realtor, where a main objective for the commercial is to concentrate the client preferences into few ...
Victoria Lopez, Matilde Santos, Javier Montero   +2 more
doaj   +1 more source

STORE: Security Threat Oriented Requirements Engineering Methodology

Journal of King Saud University: Computer and Information Sciences, 2022
As we are continuously depending on information technology applications by adopting electronic channels and software applications for our business, online transaction and communication, software security is increasingly becoming a necessity and more ...
Md Tarique Jamal Ansari, Dhirendra Pandey, Mamdouh Alenezi   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Ontology Driven Requirement Specification

JISR on Computing, 2017
Requirement engineering (RE) process is an important step of software development lifecycle and it includes a variety of activities starting with requirement elicitation to requirement documentation. This form of engineering is the backbone of a quality
Adeel Ahmed, Fabeha Maniar
doaj   +1 more source

Using Dissemination and Implementation Strategies to Evaluate Requirement Elicitation Guidelines: A Case Study in a Bed Management System

IEEE Access, 2020
Clinical software is a fundamental tool for supporting healthcare systems because it improves the quality of patient care and automatizes the most frequently performed clinical tasks. Nevertheless, since health systems include various components, such as
Gaston Marquez, Carla Taramasco
doaj   +1 more source

Using expert-elicitation to deliver biodiversity monitoring priorities on a Mediterranean island.

PLoS ONE, 2022
Biodiversity monitoring plays an essential role in tracking changes in ecosystems, species distributions and abundances across the globe. Data collected through both structured and unstructured biodiversity recording can inform conservation measures ...
J Peyton, M Hadjistylli, I Tziortzis, E Erotokritou, M Demetriou, Y Samuel, V Anastasi, G Fyttis, L Hadjioannou, C Ieronymidou, N Kassinis, P Kleitou, D Kletou, A Mandoulaki, N Michailidis, A Papatheodoulou, G Payiattas, D Sparrow, R Sparrow, K Turvey, E Tzirkalli, A I Varnava, O L Pescott   +22 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source