Results 71 to 80 of about 57,405 (292)
A Conceptual UX-aware Model of Requirements
, 2016 User eXperience (UX) is becoming increasingly important for success of software products. Yet, many companies still face various challenges in their work with UX.
Feldt, Robert +3 more
core +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
The requirement elicitation process of designing a collaborative environment – The CRE@TIVE.BIZ case
MATEC Web of Conferences, 2018 The software development industry is one that is under a constant pressure to deliver products that are innovative, fast to market and better suited to the costumers’ needs and expectations.
Alexa Lidia, Avasilcai Silvia
doaj +1 more source
Advanced Cloud Privacy Threat Modeling
, 2016 Privacy-preservation for sensitive data has become a challenging issue in cloud computing. Threat modeling as a part of requirements engineering in secure software development provides a structured approach for identifying attacks and proposing ...
Gholami, Ali, Laure, Erwin
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Capturing the Industrial Requirements of Set-Based Design for the CONGA Framework [PDF]
, 2013 The Configuration Optimisation of Next-Generation Aircraft (CONGA) is a proposed framework in a response to industrial need to enhance the aerospace capability in the UK.
Al-Ashaab, Ahmed +9 more
core
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
The conundrum of categorising requirements: managing requirements for learning on the move [PDF]
, 2004 This paper reports on the experience of eliciting and managing requirements on a large European-based multinational project, whose purpose is to create a system to support learning using mobile technology. The project used the socio-cognitive engineering
Haley, Debra +3 more
core
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source