Results 141 to 150 of about 26,437,347 (324)
FEBS Letters, EarlyView.At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom +3 more
wiley +1 more source
Analysis and Evaluation of Requirement Engineering Process at NorthBay Solutions
, 2018 Noor Afshan, Kashaf-ad-Dooja
openalex +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
A survey on future networks:application scenarios and requirements analysis
Dianxin kexue, 2019 Faced with the severe challenges of today’s network in terms of scalability,mobility,QoS guarantee and manageability,the essential capability requirements of future networks were summarized by analyzing application scenarios of future networks,and the ...
Bin DAI, Yuanyuan CAO, Yijun MO
doaj
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
ANALYSIS OF INTERNATIONAL REQUIREMENTS FOR DESIGNING OF CLINICAL TRIALS
Разработка и регистрация лекарственных средств, 2019 During the analysis of international requirements for designing of clinical trials we found that principal documents are provided by ICH. The main standard in Russian Federation is the National State Standard “Good Clinical Practice”, that is similar to ...
O. S. Kobyakova +6 more
doaj
Analysis of Intravenous Insulin Dosing Requirements for Treatment of Severe Hypertriglyceridemia
, 2022 Brittany White +2 more
openalex +2 more sources
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
On the Scenario-Based Hazard Analysis with Safety Requirements Incorporated to Assure Railway Safety [PDF]
, 2014 Ho Jeon Jung, Jae-Chon Lee
openalex +1 more source