Results 101 to 110 of about 89,500 (322)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Design Requirements for a Teledermatology Scale-up Framework

South African Computer Journal, 2018
The value proposition of full-scale teledermatology is evidenced in the literature. The public health sector of South Africa’s KwaZulu-Natal province began synchronous teledermatology in 2003, followed by spontaneous asynchronous (mobile) teledermatology
Laticha EM Walters, Richard E Scott, Maurice Mars   +2 more
doaj   +1 more source

A cost effective communication model for requirements elicitation in global software development. [PDF]

Sci Rep, 2023
Rauf MA, Bibi S, Ali S, AlSaedi T, Ur Rehman S, Mahmood K, Kundi M.   +6 more
europepmc   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Crowd-based requirements elicitation via pull feedback: method and case studies. [PDF]

Requir Eng, 2022
Wouters J, Menkveld A, Brinkkemper S, Dalpiaz F.   +3 more
europepmc   +1 more source

Data-Driven Agile Requirements Elicitation through the Lenses of Situational Method Engineering

, 2021
Xavier Franch, Aron Henriksson, Jolita Ralyté, Jelena Zdravković   +3 more
openalex   +2 more sources

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Features requirement elicitation process for designing a chatbot application

, 2022
Nurul Muizzah Johari, Puteri N. E. Nohuddin, Ahmad Hanif Ahmad Baharin, Noor Azuddin Yakob, M. J. Ebadi   +4 more
openalex   +1 more source

COMPLIANCE TO QUALITY CRITERIA OF EXISTING REQUIREMENTS ELICITATION METHODS [PDF]

In this article we define a requirements elicitation method based on natural language modelling. We argue that our method complies with synthesized quality criteria for RE methods, and compare this with the compliance of traditional RE methods (EER, ORM,
Bollen,Peter, Simons,John
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source