Results 101 to 110 of about 3,794,962 (338)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

A reference model-based user requirements elicitation process: Toward operational business-IT alignment in a co-creation value network

Information and Software Technology, 2019
Context To improve operational business-IT alignment (BITA), the development of IT-based systems should be derived from business requirements. However, the requirements elicitation process is challenging and encounters several problems which might lead ...
S. Bagheri, R. Kusters, J. Trienekens, P. Grefen   +3 more
semanticscholar   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Transforming natural language into controlled language in requirements elicitation: a pre-conceptual-schema-based conceptual synthesis

Revista Facultad de Ingeniería Universidad de Antioquia, 2014
During  the  requirements  elicitation  process,  a  group  of  analysts  and stakeholders  identify,  capture,  and  integrate  requirements.  Textual  or graphic   descriptions   capturing   the   most   relevant   concepts   from   the   domain of a ...
Bell Manrique Losada, Carlos Mario Zapata Jaramillo   +1 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Managing Ethical Requirements Elicitation

, 2023
The process of Requirements Elicitation (RE) demands from a software development team the need to communicate and engage with a variety of stakeholders, for numerous purposes regarding many aspects of the project. The aim is to translate the needs of the “customer” into accurate and actionable requirements.
Siakas, Errikos, Rahanu, Harjinder, Loveday, Joanna, Georgiadou, Elli, Siakas, Kerstin, Ross, Margaret   +5 more
openaire   +3 more sources

Getting Grip on Security Requirements Elicitation by Structuring and Reusing Security Requirements Sources

Complex Systems Informatics and Modeling Quarterly, 2015
This paper presents a model for structuring and reusing security requirements sources. The model serves as blueprint for the development of an organization-specific repository, which provides relevant security requirements sources, such as security ...
Christian Schmitt, Peter Liggesmeyer
doaj   +1 more source

Collaborative mint map tool to facilitate requirement elicitation [PDF]

, 2011
Requirements elicitation is a crucial task in any software development process.It is notable as a major contributor to the project failure.To minimize and subsequently improve the process, folding Mind Map concept in the elicitation process and ...
Abdul Hamid, Nazatul Naquiah Ahba, Atan, Mislina, Jaafar, Juliana   +2 more
core  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source