FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Ontology Construction and Evaluation of UAV FCMS Software Requirement Elicitation Considering Geographic Environment Factors [PDF]
, 2020 Xuan Hu, Jie Liu
openalex +1 more source
Crowd-based requirements elicitation via pull feedback: method and case studies. [PDF]
Requir Eng, 2022 Wouters J +3 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Eliciting Design Requirements for a Knowledge Management System in Cultural and Historical Heritage
, 2021 Néstor Nova, Rafael A. González
openalex +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Eliciting Organizational Requirements Using Stakeholder Prioritization
, 2021 openalex +1 more source
Guidelines adopted by agile teams in privacy requirements elicitation after the Brazilian general data protection law (LGPD) implementation. [PDF]
Requir Eng, 2022 Canedo ED +4 more
europepmc +1 more source
Personas based support tool for requirements elicitation [PDF]
, 2009 Lack of user understanding can bring a damaging effect to software development projects. As we acknowledge, there is a wide variety of users in each software project and consequently there are variation of goals, needs and attitudes within the ...
Ahmad, Rodina, Bavani, Mehrnaz Kazemi
core
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source