Results 71 to 80 of about 276,201 (318)

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Context-Driven Elicitation of Default Requirements: an Empirical Validation [PDF]

arXiv, 2012
In Requirements Engineering, requirements elicitation aims the acquisition of information from the stakeholders of a system-to-be. An important task during elicitation is to identify and render explicit the stakeholders' implicit assumptions about the system-to-be and its environment.
arxiv  

Evaluating Dissemination and Implementation Strategies to Develop Clinical Software [PDF]

arXiv, 2021
Clinical software has become a significant contribution to support clinical management and intra-hospital processes. In this regard, the success or failure of clinical software is mostly yielded on a suitable requirements elicitation process. Although several techniques and approaches address this process, the complexity of clinical services and the ...
arxiv  

KCS1 and VIP1, the genes encoding yeast phosphoinositol pyrophosphate synthases, are required for Ca2+‐mediated response to dimethylsulfoxide (DMSO)

FEBS Open Bio, EarlyView.
Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu, Lavinia Liliana Ruta, Claudia Valentina Popa, Simona Ghenea, Ileana Cornelia Farcasanu   +4 more
wiley   +1 more source

Transforming natural language into controlled language in requirements elicitation: a pre-conceptual-schema-based conceptual synthesis

Revista Facultad de Ingeniería Universidad de Antioquia, 2014
During  the  requirements  elicitation  process,  a  group  of  analysts  and stakeholders  identify,  capture,  and  integrate  requirements.  Textual  or graphic   descriptions   capturing   the   most   relevant   concepts   from   the   domain of a ...
Bell Manrique Losada, Carlos Mario Zapata Jaramillo   +1 more
doaj   +1 more source

Effectiveness of Preference Elicitation in Combinatorial Auctions [PDF]

arXiv, 2002
Combinatorial auctions where agents can bid on bundles of items are desirable because they allow the agents to express complementarity and substitutability between the items. However, expressing one's preferences can require bidding on all bundles. Selective incremental preference elicitation by the auctioneer was recently proposed to address this ...
arxiv  

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Getting Grip on Security Requirements Elicitation by Structuring and Reusing Security Requirements Sources

Complex Systems Informatics and Modeling Quarterly, 2015
This paper presents a model for structuring and reusing security requirements sources. The model serves as blueprint for the development of an organization-specific repository, which provides relevant security requirements sources, such as security ...
Christian Schmitt, Peter Liggesmeyer
doaj   +1 more source

Distortion Risk Measures and Elicitability [PDF]

arXiv, 2014
We discuss equivalent axiomatic characterizations of distortion risk measures, and give a novel and concise proof of the characterization of elicitable distortion risk measures. Elicitability has recently been discussed as a desirable criterion for risk measures, motivated by statistical considerations of forecasting.
arxiv