Results 61 to 70 of about 9,893 (264)
Complex Systems Informatics and Modeling Quarterly, 2015 This paper presents a model for structuring and reusing security requirements sources. The model serves as blueprint for the development of an organization-specific repository, which provides relevant security requirements sources, such as security ...
Christian Schmitt, Peter Liggesmeyer
doaj +1 more source
REQUIREMENT VALIDATION VS. REQUIREMENT ELICITATION
International Journal of Computer and Communication Technology, 2016 To support the evocation and validation of the goals achieved by the existing system and to illustrate problems of the old system, we suggest to capture current system usage using rich media (e.g., video, speech, pictures, etc.) and to interrelate those observations with the goal definitions .Therefore it becomes necessary to relate the parts of the ...
DHIRENDRA PANDEY +2 more
openaire +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Gamify4LexAmb: a gamification-based approach to address lexical ambiguity in natural language requirements [PDF]
PeerJ Computer ScienceAmbiguity is a common challenge in specifying natural language (NL) requirements. One of the reasons for the occurrence of ambiguity in software requirements is the lack of user involvement in requirements elicitation and inspection phases.
Hafsa Dar +4 more
doaj +2 more sources
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
A cost effective communication model for requirements elicitation in global software development. [PDF]
Sci Rep, 2023 Rauf MA +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Design Requirements for a Teledermatology Scale-up Framework
South African Computer Journal, 2018 The value proposition of full-scale teledermatology is evidenced in the literature. The public health sector of South Africa’s KwaZulu-Natal province began synchronous teledermatology in 2003, followed by spontaneous asynchronous (mobile) teledermatology
Laticha EM Walters +2 more
doaj +1 more source