Results 71 to 80 of about 90,563 (342)

Anticipating Requirements Changes-Using Futurology in Requirements Elicitation

International Journal of Information System Modeling and Design, 2012
It is well known that requirements changes in a later phase of software developments is a major source of software defects and costs. Thus, the need of techniques to control or reduce the amount of changes during software development projects. The authors advocate the use of foresight methods as a valuable input to requirements elicitation, with the ...
Pimentel, João Henrique, Santos, Emanuel, Castro, Jaelson, Franch Gutiérrez, Javier   +3 more
openaire   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

U-Care: Requirements Elicitation For Ambient Assisted Living [PDF]

, 2009
Western countries are facing similar trends in healthcare: population is aging, life expectations are growing, the number of healthcare professionals is decreasing, cost pressure on healthcare systems is increasing and urbanization is taking place.
Beijnum, B.J.F. van, Hermens, H.J., Klooster, J.W. van 't   +2 more
core   +2 more sources

Identifying and Modelling Complex Workflow Requirements in Web Applications [PDF]

, 2012
Workflow plays a major role in nowadays business and therefore its requirement elicitation must be accurate and clear for achieving the solution closest to business’s needs. Due to Web applications popularity, the Web is becoming the standard platform
Escalona Cuaresma, María José, Gordillo, Silvia, Retschitzegger, Werner, Rossi, Gustavo, Schwinger, Wieland, Urbieta, Mario Matias   +5 more
core   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

An Investigation of Prototyping Technique in Pakistani Software Industry

Mehran University Research Journal of Engineering and Technology, 2019
Requirements elicitation is one of the important and major activities within the Requirements Engineering phase. There are different techniques used for requirement elicitation process.
Muhammad Janas Khan, Rafiq Ahmad Khan
doaj  

A Systematic Review of AI-Enabled Frameworks in Requirements Elicitation

IEEE Access
Employing Artificial Intelligence techniques to address challenges in requirements elicitation is gaining traction. Although nine systematic literature reviews have been published on AI-based solutions in the requirements elicitation domain, to our ...
Vaishali Siddeshwar, Sanaa Alwidian, Masoud Makrehchi   +2 more
doaj   +1 more source

Issues in Requirements Elicitation [PDF]

, 1992
There are many problems associated with requirements engineering, including problems in defining the system scope, problems in fostering understanding among the different communities affected by the development of a given system, and problems in dealing with the volatile nature of requirements.
Christel, Michael G, Kang, Kyo C
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source