Results 41 to 50 of about 9,825 (217)
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
A Wargame-Augmented Knowledge Elicitation Method for the Agile Development of Novel Systems
Systems, 2020 There are inherent difficulties in designing an effective Human–Machine Interface (HMI) for a first-of-its-kind system. Many leading cognitive research methods rely upon experts with prior experiences using the system and/or some type of existing mockups
Stephen L. Dorton +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Strategies to Minimize Problems in Global Requirements Elicitation
CLEI Electronic Journal, 2008 Many challenges arise in global software development projects, most of which are related to the lack of face-to-face communication and people’s need to feel comfortable with the technology that they use. In this paper we introduce a methodology to detect
Gabriela N Aranda +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
An Investigation of Prototyping Technique in Pakistani Software Industry
Mehran University Research Journal of Engineering and Technology, 2019 Requirements elicitation is one of the important and major activities within the Requirements Engineering phase. There are different techniques used for requirement elicitation process.
Muhammad Janas Khan, Rafiq Ahmad Khan
doaj
A Systematic Review of AI-Enabled Frameworks in Requirements Elicitation
IEEE AccessEmploying Artificial Intelligence techniques to address challenges in requirements elicitation is gaining traction. Although nine systematic literature reviews have been published on AI-based solutions in the requirements elicitation domain, to our ...
Vaishali Siddeshwar +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Responsibilities in the Usability Requirements Elicitation Process [PDF]
Journal of Systemics, Cybernetics and Informatics, 2008 Like any other software system quality attribute, usability places requirements on software components. In particular, it has been demonstrated that certain usability features have a direct impact throughout the software process.
Marianella Aveledo, Ana M. Moreno
doaj