Results 41 to 50 of about 9,893 (264)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

An Investigation of Prototyping Technique in Pakistani Software Industry

Mehran University Research Journal of Engineering and Technology, 2019
Requirements elicitation is one of the important and major activities within the Requirements Engineering phase. There are different techniques used for requirement elicitation process.
Muhammad Janas Khan, Rafiq Ahmad Khan
doaj  

Strategies to Minimize Problems in Global Requirements Elicitation

CLEI Electronic Journal, 2008
Many challenges arise in global software development projects, most of which are related to the lack of face-to-face communication and people’s need to feel comfortable with the technology that they use. In this paper we introduce a methodology to detect
Gabriela N Aranda, Aurora Vizcaíno, Alejandra Cechich, Mario Piattini   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Systematic Review of AI-Enabled Frameworks in Requirements Elicitation

IEEE Access
Employing Artificial Intelligence techniques to address challenges in requirements elicitation is gaining traction. Although nine systematic literature reviews have been published on AI-based solutions in the requirements elicitation domain, to our ...
Vaishali Siddeshwar, Sanaa Alwidian, Masoud Makrehchi   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Responsibilities in the Usability Requirements Elicitation Process [PDF]

Journal of Systemics, Cybernetics and Informatics, 2008
Like any other software system quality attribute, usability places requirements on software components. In particular, it has been demonstrated that certain usability features have a direct impact throughout the software process.
Marianella Aveledo, Ana M. Moreno
doaj  

Improvement of Requirement Elicitation Process through Cognitive Psychology

Sukkur IBA Journal of Computing and Mathematical Sciences, 2017
Proper requirement elicitation is necessary for client satisfaction along with the overall project success, but requirement engineers face problems in understanding user requirements and the users of the required system fail to make requirement ...
Sana Fatima, Qamar Uddin Khand, Jawaid Ahmed Siddique, Zulfiqar Ali Memon   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Pattern-Based Automation of User Stories and Gherkin Scenarios from BPMN Models for Agile Requirement

Applied Sciences
This study enhances agile development by integrating BPMN modeling with automated functional requirements elicitation. It focuses on extracting user stories and Gherkin scenarios from BPMN process models using transformation patterns and templates.
Daniel Mateus, Denis Silva da Silveira, João Araujo   +2 more
doaj   +1 more source