Results 131 to 140 of about 150,906 (264)

Requirements Engineering Challenges in Large-Scale Agile System Development

, 2017
Agile methods have proven their value to accelerate delivery of high quality software products and services to customers. End-users have become used to regular updates that fix bugs and provide new features and for software products, short time-to-market
Swathi Gopakumar, Kasauli, Rashida, Liebel, Grischa,, Knauss, Eric, Eric Knauss, Kanagwa, Benjamin,, Grischa Liebel, Benjamin Kanagwa, Gopakumar, Swathi,, Rashidah Kasauli, Gopakumar, Swathi, Kanagwa, Benjamin, Kasauli, Rashida,, Kasauli, Rashidah,, Knauss, Eric,, Liebel, Grischa   +15 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Schema Understandability: A Comprehensive Empirical Study of Requirements Metrics

Information
Ensuring high-quality data warehouses is crucial for organizations, as they provide the reliable information needed for informed decision-making. While various methodologies emphasize the importance of requirements, conceptual, logical, and physical ...
Tanu Singh, Vinod Patidar, Manu Singh, Álvaro Rocha   +3 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Automated requirements engineering framework for agile model-driven development

Frontiers in Computer Science
IntroductionAdvances in requirements engineering, driven by various paradigms and methodologies, have significantly influenced software development practices.
Muhammad Aminu Umar, Muhammad Aminu Umar, Kevin Lano, Abdullahi Kutiriko Abubakar   +3 more
doaj   +1 more source

The Engagement between Knowledge Transfer and Requirements Engineering [PDF]

International Journal of Management, Knowledge and Learning, 2012
Developing requirements in the early phase of product development is a processthat poses considerable challenges. The most significant challenge ishow to effectively transfer knowledge-related requirements.
Mirja Vaananen, Harri Haapasalo, Anyanitha Distanont, Jari Lehto   +3 more
doaj  

Engineering Functional Requirements

Requirements Engineering (RE) is a critical sub-field of engineering that deals with identifying, analysing, specifying, modelling, and validating the user needs and constraints for a system. This not only holds for Software Engineering (SE) but for engineering in general (e.g., for building bridges and other artefacts as well).
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

On the engineering of systems of systems: key challenges for the requirements engineering community!

Software intensive systems of the future will be ultra large-scale systems of systems. Systems of Systems Engineering focuses on the interoperation of many independent, self-contained constituent systems to achieve a global need. The scale and complexity
Ncube, Cornelius
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source