Results 141 to 150 of about 150,906 (264)
Goal-Oriented Requirements Engineering: A Guided Tour
, 2001 Goals capture, at different levels of abstraction, the various objectives the system under consideration should achieve. Goal-oriented requirements engineering is concerned with the use of goals for eliciting, elaborating, structuring, specifying ...
van Lamsweerde, Axel +1 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Requirements Engineering and Machine Learning: Intentionality and the Crowd
This extended abstract summarizes a keynote given at the 8th International Workshop on Crowd-Based Requirements Engineering (CrowdRE'24), held on the 24th June 2024, in Reykjavik, Iceland, in conjunction with the 32nd IEEE International Requirements ...
Horkoff, Jennifer,
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Social issues in requirements engineering
[1993] Proceedings of the IEEE International Symposium on Requirements Engineering, 2002 Social issues in requirements engineering are classified according to what groups are involved. Topics discussed include issues within the client organization, requirement team issues, issues between the client organization and the requirements team, and development team issues. >
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
, 2004 The software industry is more than ever facing the challenge of delivering WYGIWYW software (what you get is what you want). A well-structured document specifying adequate, complete, consistent, precise, and measurable requirements is a critical ...
van Lamsweerde, Axel +1 more
core