Results 111 to 120 of about 925,044 (214)

Sector-specific clean water scarcity and competition under global change. [PDF]

NPJ Clean Water
Cárdenas Belleza GA, van Beek LPHR, Bierkens MFP, Jones ER, van Vliet MTH.   +4 more
europepmc   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Developing an Evidence-Informed Strategic Framework for Veterinary Vaccine Manufacturing Modernization Toward PIC/S GMP Compliance. [PDF]

Vaccines (Basel)
Yano T, Eiamsam-Ang T, Kewprasopsak T, Yamsakul P.   +3 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Quality requirements in clinical studies: a necessary burden?

Swiss Medical Weekly, 2003
M Salzberg
doaj   +1 more source

Variation and gaps in online pharmacy regulation: a comparative review of regulations across 12 countries. [PDF]

BMJ Public Health
Satheesh G, Nandakumar K, Palafox B, Joseph J, Panda SN, Nambiar D, Salam A, Masibo S, Wafula FPN, Tarrafeta-Sayas MB, Ravinetto R, Goodman C.   +11 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Biorisk Management in High-Containment Laboratories: Assessment of Certification Systems and Need for Global Standardization. [PDF]

Pathogens
Garbuglia AR, Zulian V, Pauciullo S, Lapa D.   +3 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Artificial Intelligence Reporting Guidelines in Radiology: A Systematic Review. [PDF]

Diagnostics (Basel)
Ochman K, Korbaś M, Kaczyńska D, Mitręga A, Zaucha R, Kufel J.   +5 more
europepmc   +1 more source