Results 141 to 150 of about 869,263 (262)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Compliance with Global Quality Requirements in Pakistan’s Export Sector

Lahore Journal of Economics
This paper describes the level of compliance with quality standards in relation to Pakistan’s top export product categories. With greater competition, innovations in technology, and stricter measures of quality being enforced, Pakistan needs to adopt a ...
Salman Ehsan, Ayesha Khanum
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

To combat poor quality research, eliminate publication requirements

EXCLI Journal : Experimental and Clinical Sciences
James Stacey Taylor
doaj   +1 more source

Telemedicine documentation in neurology and telestroke: a global scoping review. [PDF]

Neurol Sci
de Andrade JBC, Novoa CG, Pisa IT, Carneiro TS, de Oliveira NS, Rodriguez CE, Mendes GNN.   +6 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Required Quality

Concrete Journal, 2009
openaire   +2 more sources

Artificial intelligence (AI)-aided clinical data management: Applications, human-in-the-loop workflows, and regulatory considerations. [PDF]

Glob Health Med
Ohi S, Iwamoto T, Ikeda D, Kawanishi Y, Kitajima K, Ohyanagi H.   +5 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Unlocking the Value of Patient Self-Monitoring Technologies: A Multi-Country Framework to Calibrate Payer and HTA Coverage and Reimbursement Considerations with Innovation. [PDF]

J Health Econ Outcomes Res
Karichu JK, Kamaruddin S, Bilir P, Cerletti P, Chang SN, Dehipawala S, Maher C, Malyon A, O'Hara M.   +8 more
europepmc   +1 more source