AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma
ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam +10 more
wiley +1 more source
Effect of adipose tissue insulin resistance on substrate utilization during low-intensity exercise: a pilot study in young men. [PDF]
Numao S, Uchida R, Nakagaichi M.
europepmc +1 more source
ABSTRACT Background Rockered midsoles are increasingly used in running footwear, yet definitions, terminology and outcome measures vary widely across research and commercial sectors. Aim This scoping review mapped how rockers are defined in academic literature, how major footwear brands describe them and which outcome measures are most frequently ...
Priyanka Khusal +3 more
wiley +1 more source
Identification of a potential internalization or endocytic compartment-targeting signal in the C-terminal tail of the tetraspanin protein TSP-12. [PDF]
Liu Z, Williams B, Liu J.
europepmc +1 more source
ABSTRACT Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by a deficiency of aspartylglucosaminidase (AGA), a hydrolase involved in the degradation of N‐glycosylated proteins. Currently, no approved therapies are available for AGU. Development of enzyme replacement therapy (ERT) for AGU has been hampered by the complex proteolytic ...
Antje Banning +3 more
wiley +1 more source
Chronic exposure to artificial light at night dampens rhythms in locomotor activity, metabolism, and sleep in female mice. [PDF]
Meléndez-Fernández OH +6 more
europepmc +1 more source
Utility of Exogenous Ketones and Modified Atkins Diet in a Child With GSD VII (Tarui Disease)
A child with glycogen storage disease VII (Tarui disease) undertook three different diet therapies for 8 weeks each; usual diet, pre‐exercise exogenous ketones (150 mg/kg) and a modified atkins diet. Compared to usual diet, both exogenous ketones and modified atkins diet improved exercise‐induced myopathic symptoms, physical health‐related quality of ...
Kiera Batten +5 more
wiley +1 more source
Study on the effects of 4 × 4 min high-intensity interval training frequency on cardiorespiratory function, metabolic indices, and exercise performance in male university students. [PDF]
Zhang H +4 more
europepmc +1 more source
Ruffe's vitellogenic ovarian follicles consists of a single oocyte surrounded by follicular cells, a basal lamina, and thecal cells. The oocytes are polarized and covered by a primary envelope. The follicular cells diversify into micropylar and mainbody cells. The latter have dark and bright cytoplasms.
Monika Żelazowska, Roman Kujawa
wiley +1 more source

