Results 151 to 160 of about 83,179 (266)

Optimal dosing for vascular anomalies paediatric patients with population pharmacokinetic model of sirolimus

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Sirolimus is currently used off‐label for paediatric patients with vascular anomalies. However, the optimal dosage regimen for paediatric patients remains controversial. This study aimed to determine the optimal dosing regimen of sirolimus in these patients using a population pharmacokinetic (PK) model.
Seongmee Jeong, Jungryul Kim, Woojin Jung, Jiyeon Jeon, Hyeongjun Jo, Kyoung‐Bin Ryu, Ja‐Young Hong, Kwan Soo Kim, Seongjun Yang, Hee Young Ju, Hwi‐yeol Yun, Jung‐woo Chae, Keon Hee Yoo, Soyoung Lee   +13 more
wiley   +1 more source

When normalization induces correlation: shared and unstable references can create hidden dependencies. [PDF]

NPJ Syst Biol Appl
Fukutani KF, Hampton TH, Santiago MLA, de Oliveira EJF, MacKenzie TA.   +4 more
europepmc   +1 more source

Applying machine learning to pharmacovigilance data: A proof‐of‐concept study

British Journal of Clinical Pharmacology, EarlyView.
Aim Machine learning (ML) applications in pharmacovigilance remain limited and underexplored. Using data from the French National pharmacovigilance database (FNPV), this proof‐of‐concept study aimed to assess the feasibility of using a ML algorithm—eXtreme Gradient Boosting (XGBoost)—combined with SHapley Additive exPlanations (SHAP) analysis, to ...
Romain Barus, Pauline Schiro, Jean‐Luc Faillie, Romane Freppel, Johana Béné, Claire de Canecaude, François Montastruc   +6 more
wiley   +1 more source

Unveiling student sentiment dynamics toward AI‐based education through statistical analysis and Monte Carlo simulation

British Educational Research Journal, EarlyView.
Abstract This study explores the multifaceted dynamics of student sentiment towards artificial intelligence (AI)‐based education by integrating sentiment analysis techniques with statistical methods, including Monte Carlo simulations and decision tree modelling, alongside qualitative grounded theory analysis.
Volkan Duran, Ercümend Ersanlı, Hurinur Çelik   +2 more
wiley   +1 more source

Elevated sCD25 predicts early infection in patients with major burns. [PDF]

Crit Care
Hurtado-Navarro L, Flores-Cabeza E, Mata-Martínez P, Sánchez-Sánchez M, Terrón-Arcos V, Martín-Flórez C, Cachafeirio L, Vejo-Gutiérrez J, Fernández-Felipe J, Lozano-Rodríguez R, Córdoba L, de Santa María-Diez GS, Del Prado-Montero J, Rigor-Pérez JG, de Diego RP, Del Fresno C, Cueto FJ, López-Collazo E.   +17 more
europepmc   +1 more source

Machine Learning Models of Phase Contrast Images Predict Efficiency of Human Pluripotent Stem Cell Differentiation to Cardiomyocytes

Biotechnology and Bioengineering, EarlyView.
Human pluripotent stem cells were differentiated to cTnT+ cardiomyocytes and imaged throughout the process using phase contrast. We predicted differentiation efficiency (cTnT+ area) from phase contrast and compared model performance with a live‐cell cTnT‐GFP reporter.
Austin K. Feeney, Yaniv Ovadia, Aaron D. Simmons, Christian Elabd, Claire J. Peplinski, Frank Li, Sean P. Palecek   +6 more
wiley   +1 more source

Particle Filtering-Based In-Flight Icing Detection for Unmanned Aerial Vehicles. [PDF]

Sensors (Basel)
Souanef T, Tadjine M, Horri N, Chaabeni I, Boulassel B.   +4 more
europepmc   +1 more source

Brain Health Deviation Index: A Comprehensive Brain Health Assessment Biomarker for Predicting Cognitive Decline and Polyvascular Stenosis

Brain Health, EarlyView.
ABSTRACT Assessing and quantifying brain health remains a pressing challenge, despite its importance for overall well‐being. Traditional methods that focus on isolated brain measures often fail to capture the multifaceted nature of brain health and may miss early signs of dysfunction.
Ziyang Liu, Shaodong Ding, Hao Liu, Jing Jing, Jian Cheng, Huaguang Zheng, Jiyang Jiang, Wei Wen, Zhe Zhang, Wanlin Zhu, Shiping Li, Yuesong Pan, Xueli Cai, Yijun Zhou, Chang Liu, Xia Meng, Yilong Wang, Hao Li, Yong Jiang, Haijun Niu, Nicole Kochan, Henry Brodaty, Tiemin Wei, Yubo Fan, Zixiao Li, Perminder S. Sachdev, Tao Liu, Yongjun Wang   +27 more
wiley   +1 more source

Integrated analysis of transposon insertion sequencing and pangenome reveals core and lineage-specific essential genes in <i>Mycobacterium avium</i> subsp. <i>hominissuis</i>. [PDF]

Microb Genom
Sawai K, Ikai M, Shinohara M, Nishiuchi Y, Fujiyoshi S, Doi Y, Iwamoto T, Arikawa K, Maruyama F, Minato Y.   +9 more
europepmc   +1 more source

The Impact of Sustainability Orientation and Sustainability Challenges in SME Responses to Institutional Support

Business Strategy and the Environment, EarlyView.
ABSTRACT SMEs receive increasing institutional support to embed sustainability, yet they vary widely in their ability to translate such support into practice. This study addresses this gap by examining the internal cognitive and strategic mechanism (sustainability orientation) through which managers interpret institutional support and the contextual ...
Michael Zisuh Ngoasong, Aqueel Imtiaz Wahga, Sam Zisuh Njinyah, Yen‐Jung Tseng   +3 more
wiley   +1 more source