Results 41 to 50 of about 93,046 (267)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers +19 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian +6 more
wiley +1 more source
Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad +22 more
wiley +1 more source
Research on absolute ranging technology of resampling phase comparison method based on FMCW
Open Physics, 2023 As an advanced optical precision ranging method, FMCW (frequency-modulated continuous-wave) laser interferometric ranging technology can achieve a large-scale and high-precision absolute distance measurement, so it has high research and application value
Sun Bin +4 more
doaj +1 more source
Efficiency and Robustness in Resampling
The Annals of Statistics, 1992 The goal of this paper is to provide a unified framework for classifying different jackknife and bootstrap procedures for linear regression models into two types, type \(E\) (the efficient ones) and type \(R\) (the robust ones). After an introductory first section, section 2 addresses the simple linear regression model \(Y_ i=x_ i\beta+\varepsilon_ i\)
Liu, Regina Y., Singh, Kesar
openaire +3 more sources
Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph +5 more
wiley +1 more source
Frontiers in Environmental Science, 2022 The Tibetan Plateau is the most extensive high-elevation grassland on Earth, with the largest expanse of high-elevation permafrost. It is experiencing climate warming that is projected to continue at rates above the global mean, potentially jeopardizing ...
Yan Yang +6 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong +10 more
wiley +1 more source
Measuring the Effectiveness of Adaptive Random Forest for Handling Concept Drift in Big Data Streams
Entropy, 2021 We are living in the age of big data, a majority of which is stream data. The real-time processing of this data requires careful consideration from different perspectives.
Abdulaziz O. AlQabbany, Aqil M. Azmi
doaj +1 more source
microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan +4 more
wiley +1 more source