Results 111 to 120 of about 12,132,150 (278)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Design of Application Management Software of Multimedia Rescue Communication System
Gong-kuang zidonghua, 2012 In view of problems of limited information, dispersed storage data and single function of current mine rescue software, the paper proposed a design scheme of application management software of multimedia rescue communication system which can coordinate ...
LI Wen-feng +3 more
doaj
HeliyonDuring the rescue and relief work of social emergency rescue organizations, the rescue team members face significant responsibilities and risks. Social rescue organizations need to improve funding, available equipment and other aspects compared with ...
Mengyao Wang +3 more
doaj +1 more source
Problems in Disaster Rescue Work in Taiwan [PDF]
Prehospital and Disaster Medicine, 2002 Kuang-Jui Chang +4 more
openaire +1 more source
[Alternative experiences rescuing knowledge for working processes in health].
Revista da Escola de Enfermagem da U S P, 2012 O presente trabalho trata-se de um estudo descritivo de abordagem qualitativa, que objetivou compreender o processo de trabalho de enfermeiros e médicos da Estratégia Saúde da Família (ESF), do município de João Pessoa-PB, e identificar as estratégias e táticas alternativas desenvolvidas.
Oliveira, Ana Karla Sousa de +4 more
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Scandinavian Journal of Trauma, Resuscitation and Emergency MedicineBackground Increasing mountain activity and decreasing participant preparedness, as well as climate change, suggest needs to tailor mountain rescue. In Sweden, previous medical research of these services are lacking.
Anton Westman, Johanna Björnstig
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source