Results 101 to 110 of about 27,646,725 (306)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Is economic analysis of projects still useful? [PDF]
The author argues for a shift in the focus of economic analysis of projects. First, project analysts need to make full use of project information, especially identifying the source of the divergence between market prices and economic costs as well as the
Belli, Pedro
core
The Youth and AIDS Projects Style Guide
, 2020 This style guide was created by students enrolled in McKinley Green's community engaged learning section of WRIT 3671 during spring semester 2020.Students in WRIT 3671: "Visual Rhetoric and Document Design" partnered with The Youth and AIDS Projects, a ...
Students enrolled in WRIT 3671 +2 more
core
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
The Student as Scientist: Secondary Student Research Projects in Astronomy
, 2000 Student research projects are becoming either integral or optional components of Science curricula in several countries. They provide a valuable opportunity for high school students to experience many of the joys and frustrations that make up the ...
Hollow, Robert P.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Ra Ximhai, 2015 Based on the mission and vision of Indigenous Autonomous University of Mexico the idea to form a Corps Academic Degree in Accounting education program, whose mission is to develop the culture of research in each of the Education Facilitators and the ...
Anet Yuriria de Jesús López-Corrales +2 more
doaj
Goodbye to Projects? - Review of development interventions and livelihoods approaches in Uganda
, 2002 Approaches to projects and development have undergone considerable change in the last decade with significant policy shifts on governance, gender, poverty eradication, and environmental issues.
Muhumuza, F., Toner, Anna L.
core
Cohesive sediment research - a database of UK projects (SR 217) [PDF]
, 1989 Hydraulics Research (HR) and the Department of the Environment (DoE) have jointly funded research with the objective of collaborating with University and Polytechnic researchers in the field of cohesive sediments.
Hydraulics Research Wallingford, -
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source