Results 131 to 140 of about 1,301,492 (295)
Applied SciencesTo investigate the dynamic mechanical properties of water-saturated fissure rock at different strain rates, prefabricated sandstone specimens with a 45° dip angle were treated with water saturation and the impact compression test was performed with a ...
Qi Ping +6 more
doaj +1 more source
The impact of industry-university-research projects on biopharmaceutical companies' innovation performance: moderating roles of government subsidies for innovation. [PDF]
Front Public Health, 2023 Xia Y, Jia Y.
europepmc +1 more source
Synaptic Depression and Cortical Gain Control [PDF]
, 1998 Defense Advanced Research Projects Agency and Office of Naval Research (N00014-92-J-1309, N00014-95-1-0409, N00014-95-I ...
Grossberg, Stephen
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Assuming the Challenge of Developing Research Projects in Occupational Health Nursing. [PDF]
Med Lav, 2023 González-Caballero J.
europepmc +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Characterizing Canadian funded partnered health research projects between 2011 and 2019: a retrospective analysis. [PDF]
Health Res Policy Syst, 2023 Sibley KM +9 more
europepmc +1 more source