Results 151 to 160 of about 27,646,725 (306)

Scoping review of community health participatory research projects in Ghana. [PDF]

Glob Health Action, 2022
Kretchy IA, Okoibhole LO, Sanuade OA, Jennings H, Strachan DL, Blandford A, Agyei F, Asante P, Todowede O, Kushitor M, Adjaye-Gbewonyo K, Arhinful D, Baatiema L, Baatiema L, Dankyi E, Grijalva-Eternod CS, Fottrell EF, de-Graft Aikins A.   +17 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Questionnaires and risk scores: how to transform research projects into practical tools. [PDF]

J Bras Pneumol, 2023
Fernandes FLA.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ADEPT Program

, 2012
Advanced Research Projects Agency-Energy project sheet summarizing general information about the Agile Delivery of Electrical Power Technology (ADEPT) program including critical needs, innovation and advantages, impacts, and contact information.
Georgia Tech Research Corporation
core   +1 more source

Developing the next generation of renewable energy technologies: an overview of low-TRL EU-funded research projects. [PDF]

Open Res Eur, 2023
Pérez Caballero LM, Neira D'Angelo F, Tschentscher R, Gottschalk A, Salem AM, Carbonell D, Dudita-Kauffeld M, Bruch A, Alamaro E, Pasquini L, Ceroni P, Grozdanova A, Privitera S, Vermang B, Schulz P, Mencarelli D, Pierantoni L, Midrio M, Leithead W, Gurruchaga I, Haberl R, Vermaut J, Kauffeld M.   +22 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Analysis of Cancer Research Projects in Sub-Saharan Africa: A Quantitative Perspective on Unmet Needs and Opportunities. [PDF]

JCO Glob Oncol, 2023
Davies L, Milner DA, Shulman LN, Kyokunda L, Bedada A, Vuylsteke P, Masalu N, Jackson P, Jennings N, Odunlami A, Mtshali P, Dugan U.   +11 more
europepmc   +1 more source

GRIDS Program

, 2012
Advanced Research Projects Agency-Energy project sheet summarizing general information about the Grid-Scale Rampable Intermittent Dispatchable Storage (GRIDS) program including critical needs, innovation and advantages, impacts, and contact information ...
United Technologies Research Center
core  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source