Results 131 to 140 of about 27,646,725 (306)

Information Concerning Water Resources Research Center Projects, 1965-70

open access: yes, 1970
Water Resources Research CenterWater Resources Research Center. (1970). Information Concerning Water Resources Research Center Projects, 1965-70.
Water Resources Research Center
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Balancing Practical Uses and Ethical Concerns:The Role of Large Language Models in Scientific Research

open access: yesPerspectives of Earth and Space Scientists
The rapid adoption of artificial intelligence (AI) in scientific research is accelerating progress but also challenging core scientific norms such as accountability, transparency, and replicability.
Rahul Ramachandran, Kaylin Bugbee
doaj   +1 more source

Formulation of a research project

open access: yesIndian Journal of Dermatology, Venereology and Leprology, 2007
Gurmohan, Singh, Vineet, Kaur
openaire   +2 more sources

Policy and planning for large infrastructure projects : problems, causes, cures [PDF]

open access: yes
This paper focuses on problems and their causes and cures in policy and planning for large infrastructure projects. First, it identifies as the main problem in major infrastructure development pervasive misinformation about the costs, benefits, and risks
Flyvbjerg, Bent
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

When instability increases the effectiveness of aid projects [PDF]

open access: yes
The authors assess the effect of economic instability on the success of projects funded by the World Bank using the outcome of the projects, which is a notation of their overall success determined by the Bank's Independent Evaluation Group.
Guillaumont, Patrick, Laajaj, Rachid
core  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

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