Results 191 to 200 of about 27,646,725 (306)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Mandatory research projects during medical specialist training in Australia and New Zealand: a survey of trainees' experiences and reports. [PDF]

Med J Aust
Stehlik P, Withers C, Bourke RC, Barnett AG, Brandenburg C, Noble C, Bannach-Brown A, Keijzers GB, Scott IA, Glasziou PP, Veysey EC, Mickan S, Morgan M, Joshi H, Forrest K, Campbell TG, Henry DA.   +16 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Ten simple rules for successfully carrying out funded research projects. [PDF]

PLoS Comput Biol
Forero DA, Curioso WH, Wang W.
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Publication of pharmacy resident research projects: A systematic review and meta-analysis. [PDF]

Am J Health Syst Pharm
Behal ML, Fields PE, Cook AM, Morgan RJ, Flannery AH.   +4 more
europepmc   +1 more source

Small molecule biomarker discovery: Proposed workflow for LC-MS-based clinical research projects. [PDF]

J Mass Spectrom Adv Clin Lab, 2023
Rischke S, Hahnefeld L, Burla B, Behrens F, Gurke R, Garrett TJ.   +5 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Impact of Anatomical Research Projects for Medical Students: A Cross-Sectional Survey of Academic and Professional Skills, Clinical Aspirations and Appreciation of Anatomy. [PDF]

Clin Anat
Sinha A, Thirunavukarasu AJ, Bonshahi A, Brassett C.   +3 more
europepmc   +1 more source

Involvement of the European Medicines Agency in multi-stakeholder regulatory science research projects: experiences of staff members and project coordinators. [PDF]

Front Med (Lausanne), 2023
Saesen R, Machado M, Crifo B, Liu L, de Vries C, Herold R, Llinares Garcia J, Huys I.   +7 more
europepmc   +1 more source