Results 41 to 50 of about 27,646,725 (306)

Statistical analysis plan for a cluster-randomized crossover trial comparing the effectiveness and safety of a flexible family visitation model for delirium prevention in adult intensive care units (the ICU Visits Study)

Trials, 2018
Background Most adult intensive care units (ICUs) worldwide adopt restrictive family visitation models (RFVMs). However, evidence, mostly from non-randomized studies, suggests that flexible adult ICU visiting hours are safe policies that can result in ...
Daniel Sganzerla, Cassiano Teixeira, Caroline Cabral Robinson, Renata Kochhann, Mariana Martins Siqueira Santos, Rafaela Moraes de Moura, Mirceli Goulart Barbosa, Daiana Barbosa da Silva, Tarissa Ribeiro, Cláudia Eugênio, Daniel Schneider, Débora Mariani, Rodrigo Wiltgen Jeffman, Fernando Bozza, Alexandre Biasi Cavalcanti, Luciano Cesar Pontes Azevedo, Flávia Ribeiro Machado, Jorge Ibrain Salluh, José Augusto Santos Pellegrini, Rafael Barberena Moraes, Lucas Petri Damiani, Nilton Brandão da Silva, Maicon Falavigna, Regis Goulart Rosa   +23 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A NUMERICAL STUDY OF THE TYPE OF BEAM AND COLUMN IN VERTICAL BUILDINGS AND THE EFFECT OF WIND FORCE [PDF]

Proceedings on Engineering Sciences
The study evaluates the exhibition of various pillar and segment designs in vertical structures and their vulnerability to wind powers. It utilizes progressed limited component examination strategies to reenact the way of behaving of various primary ...
Reem Ahmed, Sahar Elaiwi, Aiham Alkubaisi   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Experimental Study on Dynamic Mechanical Properties of Sandstone Corroded by Strong Alkali

Applied Sciences, 2022
In order to analyze the effect of different corrosion times on the dynamic compression mechanical properties of sandstone, the coal mine sandstone specimens are subjected to corrosion in NaOH solution with pH 11 for 0 d, 1 d, 3 d, 7 d, 14 d, and 28 d ...
Qi Ping, Chen Wang, Qi Gao, Kaifan Shen, Yulin Wu, Shuo Wang, Shijia Sun   +6 more
doaj   +1 more source

Columbia World Projects First Forum Report on Inequality: Unequal Opportunity

, 2018
This report is the first in a series of inequality reports to be issued by Columbia World Projects (CWP), summarizing expert discussions held on different aspects of economic inequality, in an effort to identify concrete, implementable ideas for how ...
Columbia World Projects
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Information and Communication Technologies: The Preparedness of Field-level Extension Workers in Nigeria for their Aplication

Journal of Agricultural Extension, 2007
This paperinvestigates the preparedness of fieldlevel extension workers in Nigeria for the application of ICTs with particular reference to the internet.
I E Ilevbaoje,, T Arokoyo, O O Oyebanji
doaj   +4 more sources