Results 51 to 60 of about 27,646,725 (306)

Zero-dose children in Kano State, Nigeria: a multi-site qualitative study of non-initiation and social and behavioural change communication levers

Critical Public Health
Zero-dose children are increasingly concentrated in underserved communities, with progress stagnating despite improved routine immunisation coverage.
Stanley Ukpai, Judith-Ann Walker
doaj   +1 more source

Glass Works

Challenging Glass Conference Proceedings, 2010
Today’s demand for highly transparent building envelopes which are also adaptive and sustainable calls for innovative solutions in the glass design.
W. Sobek, S. Feierabend, K. Puller
doaj   +1 more source

SOLID LIPID NANOPARTICLES - EFFECT OF LIPID MATRIX AND SURFACTANT ON THEIR PHYSICAL CHARACTERISTICS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2004
Solid lipid nanoparticles (SLN) have gained increasing attention as a colloidal drug carrier system, particularly for lipophilic drugs, because SLN combine the advantages of polymeric nanoparticles, fat emulsions, and liposomes but avoiding their ...
Mohamed Abdel-Moaty, Heba Abdel-Salam, Mamdouh Ghorab   +2 more
doaj   +1 more source

Workload challenge research projects : overall summary [PDF]

, 2018
Three reports from the Independent Teacher Review Groups (DfE, 2016a; DfE, 2016b; and DfE, 2016c) included findings from the Department for Education (DfE) Workload Challenge Survey in which 56% of respondents indicated that data management caused ...
Pedder, David, Robinson, Carol, Robinson, Carol; id_orcid   +2 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Developing a national pharmaceutical research strategy in Lebanon: opportunities to bridge the gaps and reach the goals

Journal of Pharmaceutical Policy and Practice, 2022
Pharmaceutical research can be structured into clear national strategies that optimize patient health and foster innovation. The objectives of this document are to assess the need for a national pharmaceutical research strategy based on the current ...
Marwan Akel, Aline Hajj, Hala Sacre, Rony M. Zeenny, Chadia Haddad, Pascale Salameh   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source