Results 51 to 60 of about 51,656,893 (291)
Critical Public HealthZero-dose children are increasingly concentrated in underserved communities, with progress stagnating despite improved routine immunisation coverage.
Stanley Ukpai, Judith-Ann Walker
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Columbia World Projects Forum Report: Maternal Health
, 2019 Maternal health, the topic of the CWP Forum on which this report is based, is a vital concern for all societies around the world. The wellbeing of pregnant women and mothers, and the care they receive before, during, and after delivery, is integral to ...
Columbia World Projects
core +1 more source
Journal of Pharmaceutical Policy and Practice, 2022 Pharmaceutical research can be structured into clear national strategies that optimize patient health and foster innovation. The objectives of this document are to assess the need for a national pharmaceutical research strategy based on the current ...
Marwan Akel +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Summary of Research 1995, Department of Operations Research [PDF]
, 1995 The views expressed in this report are those of the authors and do not reflect the official policy or position of the Department of Defense or the U.S.
Faculty of the Department of Operations Research, Naval Postgraduate School
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SOLID LIPID NANOPARTICLES - EFFECT OF LIPID MATRIX AND SURFACTANT ON THEIR PHYSICAL CHARACTERISTICS [PDF]
Bulletin of Pharmaceutical Sciences. Assiut University, 2004 Solid lipid nanoparticles (SLN) have gained increasing attention as a colloidal drug carrier system, particularly for lipophilic drugs, because SLN combine the advantages of polymeric nanoparticles, fat emulsions, and liposomes but avoiding their ...
Mohamed Abdel-Moaty +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source