Results 51 to 60 of about 1,301,492 (295)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Glass Works

Challenging Glass Conference Proceedings, 2010
Today’s demand for highly transparent building envelopes which are also adaptive and sustainable calls for innovative solutions in the glass design.
W. Sobek, S. Feierabend, K. Puller
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Neural Models of Normal and Abnormal Behavior: What Do Schizophrenia, Parkinsonism, Attention Deficit Disorder, and Depression Have in Common? [PDF]

, 1998
Defense Advanced Research Projects Agency and Office of Naval Research (N00014-95-1-0409); National Science Foundation (IRI-97 ...
Abbott, Aggleston, Albert, Andreasen, Andreason, Arndt, Baddeley, Baloch, Banquet, Banquet, Barbas, Bleuler, Blumer, Bower, Bradski, Braff, Briley, Brown, Brunia, Bullock, Bullock, Bullock, Bullock, Buonomano, Cant, Carlsson, Carpenter, Carpenter, Carpenter, Carpenter, Carpenter, Carpenter, Chang, Contreras-Vidal, Contreras-Vidal, Contreras-Vidal, Cox, Davis, Denny, Desimone, Dews, Early, Ellinwood, Estes, Estes, Evarts, Felleman, Fiala, Francis, Francis, Francis, Frith, Frith, Fuster, Fuster, Fuster, Gaudiano, Gaudiano, Gerlach, Gilbert, Gloor, Gochin, Goldman-Rakic, Grace, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Grossberg, Halgren, Harries, Hodgkin, Horak, Horak, Hornykiewicz, Ingvar, Irwin, Ito, Johnson, Kalaska, Kamin, Kamin, Koester, Kornhuber, Kraepelin, Kuhar, LeDoux, Leibowitz, Levitt, Liddle, Lloyd, Low, Lynch, Macchi, MacLennan, Magee, Maher, Maher, Markram, Masterson, McAdam, McAdam, McAllister, McAllister, Milner, Mirsky, Mishkin, Mishkin, Netter, Näätänen, Näätänen, Pantelis, Pantelis, Pavlov, Pilowsky, Rammsayer, Renault, Reynierse, Reynolds, Reynolds, Reynolds, Riklan, Sauer, Schallert, Schallert, Schallert, Sekuler, Shaywitz, Shekim, Sillio, Squire, Staddon, Stevens, Swanson, Tecce, Teulings, Thompson, Torrey, Tsumoto, Ungerleider, Valenstein, Van Gemmert, von Helmholtz, von Helmholtz, Wallach, Walter, Weber, Weinberger, Weiner, Weiss, Wolgin, Zuckerman, Ögmen, Ögmen   +177 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

SPARKPLUS for Self- and Peer Assessment on Group-Based Honours’ Research Projects [PDF]

, 2010
This paper explores an application of an online tool SPARKPLUS (Self and Peer Assessment Resource Kit) for the self and peer assessment on the group-based Honours’ research projects.
Chanda, E., Willison, J., Wu, C.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source