Results 241 to 250 of about 70,430,026 (358)

Hopes that business leaders in parliament will promote reforms may be premature [PDF]

, 1998
Research, Update
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Administrative reform in Ukraine: has the threshold been passed? [PDF]

, 2000
Research, Update
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

An emerging TIMER-2C framework for addressing barriers to research culture and productivity among local healthcare providers in the Middle East and sub-Saharan Africa: A qualitative study and modified Delphi approach. [PDF]

PLOS Glob Public Health
Odeny B, Mangale D, Sharma D, Balogun M, Bukusi E, Suleman F, Derbew M, Iwelunmor J, Birru E, Ngang IC, Anandarajah A, Mamillapalle V, Almahmeed W.   +12 more
europepmc   +1 more source

Divided we stand... [PDF]

, 1999
Research, Update
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

What Are the Characteristics of Households That Purchase Alcohol-Free and Low-Alcohol Drinks in Great Britain in 2018 and 2021? [PDF]

Drug Alcohol Rev
Clarke ZL, Pryce R, Holmes J, Stevely AK, Wilson LB, Kersbergen I.   +5 more
europepmc   +1 more source

A conversation with Loren Miller, MD, MPH, professor and chief, Division of Infectious Diseases, Lundquist Institute at Harbor-UCLA

Journal of Clinical and Translational Science
Clinical Research Forum
doaj   +1 more source

Illegitimate legislature? [PDF]

, 1998
Research, Update
core