Results 261 to 270 of about 50,155,014 (329)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Research joint ventures, product differentiation, and price collusion

, 2002
Luca Lambertini, Sougata Poddar, Dan Sasaki   +2 more
openalex   +2 more sources

What are the limits to biomedical research acceleration through general-purpose AI? [PDF]

Sci Rep
Hebenstreit K, Convalexius C, Reichl S, Huber S, Bock C, Samwald M.   +5 more
europepmc   +1 more source

Hopes that business leaders in parliament will promote reforms may be premature [PDF]

, 1998
Research, Update
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The knowledge-based view in international business: A systematic review of the literature and future research directions

Maria-Cristina Stoian, Janja Annabel Tardios, Marios Samdanis   +2 more
openalex   +1 more source

An Experiential Approach to Research in Planning

, 2010
Thomas Straatemeier, Luca Bertolini, Marco te Brömmelstroet, Perry Hoetjes   +3 more
openalex   +2 more sources

What Is My Role? A Qualitative Study of Labor, Birth, and Postpartum Experiences of Partners. [PDF]

Nurs Health Sci
Pereda-Goikoetxea B, Fiaño-Santos M, Tomas-Riscado S, Uranga-Iturriotz M, Huitzi-Egilegor JX.   +4 more
europepmc   +1 more source

Administrative reform in Ukraine: has the threshold been passed? [PDF]

, 2000
Research, Update
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source