Results 101 to 110 of about 5,954,043 (302)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Convergence and Optimality of Adaptive Mixed Methods on Surfaces [PDF]

open access: yes, 2014
In a 1988 article, Dziuk introduced a nodal finite element method for the Laplace-Beltrami equation on 2-surfaces approximated by a piecewise-linear triangulation, initiating a line of research into surface finite element methods (SFEM). Demlow and Dziuk
Holst, Michael   +2 more
core   +1 more source

BMI-for-age graphs with severe obesity percentile curves: Tools for plotting cross-sectional and longitudinal youth BMI data [PDF]

open access: yes, 2017
Background Severe obesity is an important and distinct weight status classification that is associated with disease risk and is increasing in prevalence among youth.
Clark, B. Ruth   +3 more
core   +2 more sources

NKCC1: A key regulator of glioblastoma progression

open access: yesMolecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen   +5 more
wiley   +1 more source

Asymmetries of knowledge between children and teachers on a New Zealand bush walk [PDF]

open access: yes
This article presents the analysis of a single case interaction between two preschool children aged four-years-old and their male early childhood teacher during a routine excursion to the New Zealand bush.
Amanda Bateman, Jane Waters
core  

Community business in Scotland: an alternative vision of 'enterprise culture', 1979-97 [PDF]

open access: yes, 2018
The force and coherency with which Margaret Thatcher and her inner circle outlined their vision for ‘enterprise culture’, like so many aspects of Thatcherism, have masked the complexity of its origins and the histories of alternative responses.
Murray, Gillian
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Response to Wang and Luo

open access: yesBMC Biology, 2012
This article is a response to Wang and Luo. See correspondence article http://www.biomedcentral.com/1741-7007/10/30 and the original research article http://www.biomedcentral.com/1741-7007/9/24.
Rehmsmeier Marc
doaj   +1 more source

Writing business research article abstracts

open access: yesIbérica, 2012
A great deal has been published about oral and written genres in business (e.g., letters, research articles, oral presentations, etc.), and less attention has been paid to business research article abstracts as a written genre, as many experts would argue.
openaire   +1 more source

Philosophic-Historical Truths Confer Juventus Winner of 2018/2019 UEFA Champions League [PDF]

open access: yes, 2018
This article is a summarization of a research paper titled The Philosophy of the UEFA Champions League. Both the summary and the paper puts forward the hypothesis which seeks to prove and establish the real existence of metaphysics in the cosmos ...
Adeyemi, Opeyemi
core   +2 more sources

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