Results 141 to 150 of about 3,460,507 (274)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Temporal and spatial relations between patents and scientific journal articles: the case of nanotechnologies [PDF]

open access: yes
Patent citations have been widely used in order to study inter-technology and science-technology relations. The present work aims at: i) exploring time relations and distance between technical/innovative activities and scientific knowledge, using journal
Ugo Finardi
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Moves in the Introduction Sections of Applied Linguistics Research Articles

open access: yesBaltic Journal of English Language, Literature and Culture, 2015
Interest in the research article as a representative of a genre in different disciplines has resulted in many studies, which are essential for English for Academic Purposes.
Monta Farneste
doaj  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Tackling genre classification: the case of HTML research articles [PDF]

open access: yes, 2007
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Comunicação e Expressão. Programa de Pós-Graduação em Letras/Inglês e Literatura CorrespondentePesquisas recentes sobre comunicação científica têm revelado que desde o final dos anos de
Hendges, Graciela Rabuske
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Research Article.

open access: yesJournal of eye movement research
In this study, we demonstrate the effects of anxiety and cognitive load on eye movement planning in an instrument flight task adhering to a single-sensor-single-indicator data visualisation design philosophy. The task was performed in neutral and anxiety conditions, while a low or high cognitive load, auditory n-back task was also performed.
Jonathan, Allsop   +3 more
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

El discurso científico de la historia: Análisis estructural y retórico de los artículos de investigación en historia THE SCIENTIFIC DISCOURSE OF HISTORY: A STRUCTURAL AND RHETORICAL ANALYSIS OF HISTORY RESEARCH ARTICLES

open access: yesBoletín de Filología, 2012
Al igual que en cualquier otra disciplina científica, el discurso general de la historia se transmite a través de distintos géneros, siendo el artículo de investigación (en adelante, AI), una manifestación que permite, en particular, analizar el discurso
Miguel Fuentes Cortés
doaj  

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