Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Medisan, 2012 La universidad debe preservar, desarrollar y promover la cultura de la humanidad a través de sus procesos sustantivos y vínculo con la sociedad, lo cual puede lograr a través de la investigación científica, que constituye además una función esencial de ...
Nilia Victoria Escobar Yéndez +2 more
doaj
METHODICAL MAINTENANCE SYNERGISTIC AND RATIONAL APPROACHS TO TEACHING CHEMISTRY IN HIGH SCHOOL
Sovremennye Issledovaniâ Socialʹnyh Problem, 2016 At present, we can say the search for new forms and methods of teaching. The most important area of research is to create a teaching environment that allows to realize the goal of building an effective learning process, contributing to the development of
Sergey Alexsandrovich Zolotykhin
doaj +1 more source
Achieving research competences through medical education [PDF]
Perspectives on Medical Education, 2013 None
openaire +3 more sources
THE EFFECTS OF SALESPERSON TRAINING PROGRAM QUALITY ON SALESPERSON COMPETENCY AND MANAGEMENT OF THE DISTRIBUTION AREA TO INCREASE SALESPERSON PERFORMANCE (Differences Study on Distribution Pharmacy Company in Central Java, Indonesia) [PDF]
, 2017 A quality training program for sales persons will optimize sales persons’ performance through several variables, which are the competence of sales persons and the quality of distribution territory management.
Ferdinand, Augusty Tae +2 more
core
Divorce and the multidimensionality of men and women's mental health: the role of social-relational and socio-economic conditions [PDF]
, 2014 Research consistently reveals that the divorced generally face more mental health problems than the married. Less attention however has been paid to positive mental health indicators.
Bracke, Piet +3 more
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Social and Cultural Capital and Learners’ Cognitive Ability: Issues and Prospects for Educational Relevance, Access and Equity Towards Digital Communication in Indonesia [PDF]
, 2020 In the educational context, the necessity of recognizing the structure of relations among social and educational institutions by examining how individuals’ different social and cultural experiences affect the educational learning outcomes towards global ...
Maunah, Binti
core +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Health-Saving Competence of Future Primary School Teachers: Indicators of Development [PDF]
, 2020 The research revealed an increasing interest of scientists to the problem of formation of health-saving competence of future primary school teachers. This tendency is due to the need for a social inquiry to modernize the training of future educators ...
Бондаренко, Геннадій Леонідович +5 more
core