Results 161 to 170 of about 56,063,487 (256)

Where are my Black professors? The research culture preventing Black researchers from thriving in UK institutions. [PDF]

Wellcome Open Res
Essilfie-Quaye S, Reddy SP, Adeturinmo M, Lloyd CM, Morgan W.   +4 more
europepmc   +1 more source

Partnering patients, caregivers, and basic scientists: an engagement model that fosters patient- and family-centered research culture. [PDF]

Transl Res, 2021
Ketcher D, Bidelman A, Le LQ, Otto AK, Lester DK, Amtmann-Beuttner KK, Gonzalez BD, Wright KL, Vadaparampil ST, Reblin M, Lau EK.   +10 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Shifting research culture to address the mismatch between where trials recruit and where populations with the most disease live: a qualitative study. [PDF]

BMC Med Res Methodol, 2021
Rai T, Dixon S, Ziebland S.
europepmc   +1 more source

The Will to Technology and the Culture of Nihilism

, 2004
A multimedia/print book launch and lecture. The Will to Technology and the Culture of Nihilism explores the future of the twenty-first century in the language of technological destiny.
Kroker, Arthur
core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Summer days: research culture and the neuroscience of taking a break. [PDF]

Brain Commun
Spires-Jones TL.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

A scoping review on what constitutes a good research culture. [PDF]

F1000Res
Blatch-Jones AJ, Lakin K, Thomas S.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source