Results 191 to 200 of about 25,624,885 (337)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Review report on extended abstract titled "Open Data and Researcher Assessment in the Social Sciences and Humanities (SSH): Addressing Challenges and Building Tailored Support"

Peroni, Silvio, Vergoulis, Thanasis
openalex   +1 more source

Sharing and reuse of mental health research data: Introducing the HeSANDA mental health node. [PDF]

Australas Psychiatry
Yung AR, Zivanov N, Milicevic M, Kang K, Thompson A, Turner A, Barutchu A, Llorente L, Samuel D, Dean OM, Williams R, Lavoie S.   +11 more
europepmc   +1 more source

Research Data Management in Natural History [PDF]

, 2018
Donaldson, Mary
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Table 2_Bibliometric trends and patterns in Tasar silkworm (Antheraea mylitta) research: a data report (1980–2024).docx

J. Komal (21216617), R. Gowrisankar (21216620), Vishaka G. V. (21216623), H. Nadaf (21216626), Ipsita Samal (21216629), Pasumarthi Venkata Dinesh Kumar (21216632), C. Selvaraj (722035), B. Thirupam Reddy (21216635), T. Selvakumar (708647), Deepak Kumar Mahanta (12254675), Tanmaya Kumar Bhoi (21216638)   +10 more
openalex   +1 more source

Experiences of Health Research Data Sharing Among Researchers in Sub-Saharan Africa: Cross-Sectional Study. [PDF]

JMIR Form Res
Sukums F, Ngowi B, Chaula R, Weiszhar KL, Kalinga A, Ivanova O, Prazeres da Costa C, Hoerauf A, Sahay S, Noormahomed EV, Debrah LB, Sikasunge C, Ngowi H, Winkler AS.   +13 more
europepmc   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Singlebeam Echosounder data collected during research cruise NA166 using a Knudsen 3260 instrument system onboard the platform EV Nautilus

Rolling Deck to Repository
openalex   +1 more source

Development of cardiovascular clinical research data warehouse and real-world research. [PDF]

J Geriatr Cardiol
Li DD, Yu YN, Sun ZJ, Liu CF, Chen T, Shan DK, Tuo XD, Guo J, Chen YD.   +8 more
europepmc   +1 more source