Results 211 to 220 of about 15,898,430 (313)

Applicability of Existing Gender Scores for German Clinical Research Data: Scoping Review and Data Mapping. [PDF]

JMIR Med Inform
Schindler L, Beelich H, Katsari E, Liprandi D, Stracke S, Waltemath D.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Sharing EHR data of patients with rare diseases for research - The role of quality assessments in a national federated research data infrastructure. [PDF]

BMC Med Inform Decis Mak
Tahar K, Verbuecheln R, Martin T, Graessner H, Biergans S, Krefting D.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Journal research data policies in materials science.

Digit Discov
Hörmann L, Myneni H, Al-Hamd RKS, Batalović K, Bonfanti S, Grasselli F, Gražulis S, Koç B, Konstantinou K, Lončarić I, Lopanitsyna N, Oliveira JM, Pegolo P, Ramos P, Rossi K, Schwaminger SP, Simmen E, Todorović M, Stricker M, Schmidt J.   +19 more
europepmc   +1 more source

Rooting for data: A FAIR research data management and data analysis environment for the PlantMicrobe research collaboration. [PDF]

PLoS Pathog
Dröst F, Eberhardt U, Wellmann A, Saker H, Pirkl S, Krinninger M, Klingl A, Kemen E, Kamal N, Hachinger S, Krüger J.   +10 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evolve with your research: stepwise system evolution from document-driven to fact-centric research data management in materials science. [PDF]

J Cheminform
Dudarev V, Ludwig A.
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Sharing and reuse of mental health research data: Introducing the HeSANDA mental health node. [PDF]

Australas Psychiatry
Yung AR, Zivanov N, Milicevic M, Kang K, Thompson A, Turner A, Barutchu A, Llorente L, Samuel D, Dean OM, Williams R, Lavoie S.   +11 more
europepmc   +1 more source