Results 191 to 200 of about 26,127,127 (290)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Experiences of Health Research Data Sharing Among Researchers in Sub-Saharan Africa: Cross-Sectional Study. [PDF]

JMIR Form Res
Sukums F, Ngowi B, Chaula R, Weiszhar KL, Kalinga A, Ivanova O, Prazeres da Costa C, Hoerauf A, Sahay S, Noormahomed EV, Debrah LB, Sikasunge C, Ngowi H, Winkler AS.   +13 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Pilot Project to Evaluate the Benefit of Additional Support in Haematopoietic Cell Transplant (HCT) Research Data Management on Behalf of Anthony Nolan and BSBMTCT. [PDF]

EJHaem
Hewerdine S, Judge G, Lee J, Braund H, Allen H, Snowden JA, Carpenter B, Blake H, Venayakamoorthy Y, Potter V, Smith T, Vermeir L, Marsh SGE, Mayor NP.   +13 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Planning for New Threats to Online Research Data Validity: The Issue of Computer-Using Agents. [PDF]

Eval Health Prof
Agley J.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A roadmap for navigating child health research data sharing across Canada and beyond - building on UCAN CAN-DU. [PDF]

Pediatr Rheumatol Online J
Gerber B, Currie GR, Mosoiu A, Bernier A, Bernier FP, Boycott KM, Fiebelkorn G, Hens K, Knoppers BM, LeBlanc C, Scherer SW, Shaw D, Viney C, Virtanen C, Benseler SM, Yeung RSM, Marshall DA.   +16 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Interpreting discordant results in mixed-method research: data triangulation, participant voices, and epistemic issues in health research. [PDF]

Int J Soc Res Methodol
Page-Reeves J, Rivera M, Lozano E, Regino L, Tellez M, Mendivil-Aguayo P, Moore M, Rodriguez DP, Kalvesmaki A, Crocker R, Aragon A, Vasquez C, Perez J, Thomas RJ, Bearer EL, Murray-Krezan C.   +15 more
europepmc   +1 more source