Results 91 to 100 of about 71,329,028 (292)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Data Management and Sharing Plan for: Collaborative Research: Cross-Cutting Improvements: Open Science Roadmap for Research Infrastructures

The Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project ...
Mandal, Anirban
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Supporting Data Discovery: Comparing Perspectives of Support Specialists and Researchers

Data Science Journal
Purpose: Much of the research in data discovery is centered on the users’ viewpoint, frequently overlooking the perspective of those who develop and maintain the discovery infrastructure.
Guangyuan Sun, Tanja Friedrich, Kathleen Gregory, Brigitte Mathiak   +3 more
doaj   +1 more source

Data Management and Sharing Plan for: Rapid Response to Requests for Rural Data Analysis and Issue Specific Rural Research Studies

The Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project ...
Malone, Tyler
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Do-It-Yourself Research Data Management Training Kit for Librarians

, 2013
The DIY Research Data Management Training Kit for Librarians is a pilot RDM course for aimed at librarians covering five topics involving reading assigments from the MANTRA course (http://datalib.edina.ac.uk/mantra/), reflective writing, and 2-hour face ...
EDINA and Data Library, University of Edinburgh
core  

Data Management and Sharing Plan for: Multistate Dementia Care Research Center - Partnership and Engagement Core

The Data Management and Sharing Plan describes the scientific data to be generated and/or used in the research and outlines a strategy for managing and sharing project ...
Zimmerman, Sheryl
core   +1 more source

LSHTM Research Data Management Policy - Support documents [PDF]

, 2018
The Research Data Management Policy outlines a set of principles with which LSHTM staff and students should follow to ensure their Research Data is managed in accordance with good research practice.
LSHTM Library, Archive & Open Research Service, LSHTM Library & Archives service   +1 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source