Results 111 to 120 of about 9,082,977 (268)
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Data Sharing: International and National Approaches
Iranian Journal of Information Processing & Management, 2018 Information and Communication Technologies (ICTs) have significant role in producing research data in different scientific fields. These data not only lead to generates fields based on research data but also caused to produce a new paradigm or approach ...
Esmaeil Vaziri, ,
doaj
Needs assessment towards research data management at the Medical Faculty of the University of Freiburg - Data of the BE-KONFORM study. [PDF]
Data Brief, 2023 Fichtner UA +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
FAIR research data management as community approach in bioengineering. [PDF]
Eng Life Sci, 2023 Rehnert M, Takors R.
europepmc +1 more source
‘DIY’ Research Data Management Training Kit for Librarians [PDF]
, 2013 – This paper discusses extended professional development training in research data management for librarians piloted at the University of Edinburgh.
Macdonald, Stuart, Rice, Robin
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
A focus groups study on data sharing and research data management. [PDF]
Sci Data, 2022 Donaldson DR, Koepke JW.
europepmc +1 more source
A system overview of the Aerospace Safety Research and Data Institute data management programs [PDF]
The NASA Aerospace Safety Information System, is an interactive, generalized data base management system. The on-line retrieval aspects provide for operating from a variety of terminals (or in batch mode).
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source