Results 61 to 70 of about 67,799,653 (304)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Supporting Data Discovery: Comparing Perspectives of Support Specialists and Researchers

Data Science Journal
Purpose: Much of the research in data discovery is centered on the users’ viewpoint, frequently overlooking the perspective of those who develop and maintain the discovery infrastructure.
Guangyuan Sun, Tanja Friedrich, Kathleen Gregory, Brigitte Mathiak   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Research Data and Data Management Services

, 2019
Importance of research data and data management services in the changing information landscape has been exhibited in this poster. Libraries have important role in preservation and management of research data. The leading Universities and research institutions in high income countries have established data repositories and have data policies in place ...
openaire   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Research Data Services: Forschungsdatenmanagement an der UDE [PDF]

, 2019
Netzwerktag der Fakultät für Geisteswissenschaften, Universität Duisburg-EssenNetzwerktag: Digitalisierung in den Geisteswissenschaften: Digital forschen | Digitales erforschen | Lehre digital ...
openaire   +3 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

G²LM|LIC - The Impact of Subsidized Access to Nurseries and Employment Services on Mothers’ Labor Market Outcomes and Child Development in Egypt

There are three main explanations as to why female labor force participation, globally, remains low: (1) women’s high opportunity cost of time (2) weak labor demand and (3) restrictive gender norms.
Abdelrahman, Nagy, Crafft, Caroline, Crepon, Bruno, Caria, Stefano   +3 more
core   +1 more source

Forging Resilience and Building Capacity: Professional Development in Early-Career Research Data Services 

Journal of eScience Librarianship
As research and information landscapes evolve, shaped through the intentional incorporation of data services and emerging technologies like artificial intelligence (AI), academic libraries are being asked to expand service capacities, develop new ...
Samantha Harmon
doaj   +2 more sources