Results 81 to 90 of about 67,799,653 (304)

Bringing All the Stakeholders to the Table: A Collaborative Approach to Data Sharing

Journal of eScience Librarianship, 2022
Objective: This paper examines a unique data set disclosure process at a medium sized, land grant, research university and the campus collaboration that led to its creation.
doaj   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

When Demand Outpaces Capacity: The Evolution of Data Services and Support at an Academic Library

Ticker
This article explores the changing landscape of data services at Yale University's academic library and examines the evolving roles of data librarians and subject librarians in response to the increasing demand for data-related support in research.
Barbara Esty, Erin Wachowicz
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

“Data Something”: Assessing Tools, Services and Barriers for Research Data Collaboration at the University of Edinburgh

, 2020
Results from a small-scale study carried out by Dr Tamar Israeli, with support from the Research Data Support team, to gain a better understanding of the barriers and difficulties that prevent researchers from using institutional tools and services ...
Israeli, Tamar
core   +2 more sources

Tiers of Research Data Support Services

Journal of eScience Librarianship, 2012
Objective: To describe three tiers of research data support services that emerged from national environmental scanning of data management needs and activities.
Rebecca C. Reznik-Zellen, Jessica Adamick, Stephen McGinty   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Annual report/ Connecticut Department of Revenue Services. FY 2015-2016.

, 2016
Annual; Fiscal years 2003/2004 and 2004/2005 combined.; Report year ends June 30.; Prepared by the Dept.
Connecticut. Department of Revenue Services.
core  

Accuracy of Measuring Relative Poverty: Using Hong Kong as an Example

Journal of Social Computing
Defining poverty based on relative income, intended to identify individuals who are significantly worse off than the mainstream living standard—is widely adopted by more developed countries and regions, such as those in the Organization for Economic Co ...
Dah Ming Chiu, Yu Cheung Wong, Stephen Chun Chung Cheng, Felix Sai Kit Ng   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source