Results 141 to 150 of about 77,036,499 (314)
Research through design : observational research for sustainability
, 2004 The aim of this paper is to develop an effective observational research method that will foster a practical sense for sustainability in student designers.
Mellick Lopes, Abby +3 more
core
From the specificity of the project in design to social innovation by design: a contribution
, 2016 International audienceThis contribution aims to understand the specificity of thinking and making social innovation, within and through the design field and its practice.
Michela Deni +8 more
core +1 more source
Facilitating Design Research by Mapping Design Research Trajectories.
, 2014 Design research is an emerging paradigm in the study of learning. It is far from a mature methodology, as it faces a variety of difficulties, one of which is the characterization of the research process. We mapped the design trajectory proposed by Sandoval to capture the complex process of design research.
Ma, G, van Aalst, J
openaire +3 more sources
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Call for Papers for the 1973 Design Activity International Conference
, 1973 The 1973 Design Research Society Conference was held jointly with the US Design Methods Group on 29-31 August 1973 at The Polytechnic of Central London.
Design Research Society and Design Methods Group,
core
Proyectos de investigación científica en salud
Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2016 El proceso de investigación científica nace a partir de la necesidad de resolver un déficit cognitivo existente en el objeto de estudio, transita por diferentes etapas, condicionadas por factores objetivos y subjetivos.
Elso Manuel Cruz Cruz
doaj
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source